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- W2016336099 abstract "Parkinson's disease, known also as striatal dopamine deficiency syndrome, is a degenerative disorder of the central nervous system characterized by akinesia, muscular rigidity, tremor at rest, and postural abnormalities. In early stages of parkinsonism, there appears to be a compensatory increase in the number of dopamine receptors to accomodate the initial loss of dopamine neurons. As the disease progresses, the number of dopamine receptors decreases, apparently due to the concominant degeneration of dopamine target sites on striatal neurons. The loss of dopaminergic neurons in Parkinson's disease results in enhanced metabolism of dopamine, augmenting the formation of H2O2, thus leading to generation of highly neurotoxic hydroxyl radicals (OHβ. The generation of free radicals can also be produced by 6-hydroxydopamine or MPTP which destroys striatal dopaminergic neurons causing parkinsonism in experimental animals as well as human beings. Studies of the substantia nigra after death in Parkinson's disease have suggested the presence of oxidative stress and depletion of reduced glutathione; a high level of total iron with reduced level of ferritin; and deficiency of mitochondrial complex I. New approaches designed to attenuate the effects of oxidative stress and to provide neuroprotection of striatal dopaminergic neurons in Parkinson's disease include blocking dopamine transporter by mazindol, blocking NMDA receptors by dizocilpine maleate, enhancing the survival of neurons by giving brain-derived neurotrophic factors, providing antioxidants such as vitamin E, or inhibiting monoamine oxidase B (MAO-B) by selegiline. Among all of these experimental therapeutic refinements, the use of selegiline has been most successful in that it has been shown that selegiline may have a neurotrophic factor-like action rescuing striatal neurons and prolonging the survival of patients with Parkinson's disease." @default.
- W2016336099 created "2016-06-24" @default.
- W2016336099 creator A5035690233 @default.
- W2016336099 creator A5055459726 @default.
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- W2016336099 date "1996-01-01" @default.
- W2016336099 modified "2023-10-12" @default.
- W2016336099 title "Oxidative stress and antioxidant therapy in Parkinson's disease" @default.
- W2016336099 cites W1508638897 @default.
- W2016336099 cites W1935520364 @default.
- W2016336099 cites W1965563600 @default.
- W2016336099 cites W1967482164 @default.
- W2016336099 cites W1968039775 @default.
- W2016336099 cites W1968257988 @default.
- W2016336099 cites W1968790403 @default.
- W2016336099 cites W1968840823 @default.
- W2016336099 cites W1969772140 @default.
- W2016336099 cites W1970127608 @default.
- W2016336099 cites W1971025492 @default.
- W2016336099 cites W1971822391 @default.
- W2016336099 cites W1973508975 @default.
- W2016336099 cites W1976795220 @default.
- W2016336099 cites W1979243660 @default.
- W2016336099 cites W1980524690 @default.
- W2016336099 cites W1980825813 @default.
- W2016336099 cites W1981519416 @default.
- W2016336099 cites W1982752849 @default.
- W2016336099 cites W1983106271 @default.
- W2016336099 cites W1983818310 @default.
- W2016336099 cites W1984475565 @default.
- W2016336099 cites W1984940419 @default.
- W2016336099 cites W1985613988 @default.
- W2016336099 cites W1985842394 @default.
- W2016336099 cites W1987655773 @default.
- W2016336099 cites W1988750560 @default.
- W2016336099 cites W1988791308 @default.
- W2016336099 cites W1989279204 @default.
- W2016336099 cites W1991192746 @default.
- W2016336099 cites W1991511436 @default.
- W2016336099 cites W1991720146 @default.
- W2016336099 cites W1992216166 @default.
- W2016336099 cites W1993859545 @default.
- W2016336099 cites W1994138059 @default.
- W2016336099 cites W1996175319 @default.
- W2016336099 cites W1996909837 @default.
- W2016336099 cites W1997786966 @default.
- W2016336099 cites W1998023239 @default.
- W2016336099 cites W1998652318 @default.
- W2016336099 cites W1998724253 @default.
- W2016336099 cites W1998750126 @default.
- W2016336099 cites W1999014193 @default.
- W2016336099 cites W1999106451 @default.
- W2016336099 cites W1999434577 @default.
- W2016336099 cites W2001727865 @default.
- W2016336099 cites W2004280801 @default.
- W2016336099 cites W2005102504 @default.
- W2016336099 cites W2005886990 @default.
- W2016336099 cites W2008368504 @default.
- W2016336099 cites W2008963742 @default.
- W2016336099 cites W2010885353 @default.
- W2016336099 cites W2011475407 @default.
- W2016336099 cites W2011984886 @default.
- W2016336099 cites W2013826930 @default.
- W2016336099 cites W2015145167 @default.
- W2016336099 cites W2015528067 @default.
- W2016336099 cites W2015698319 @default.
- W2016336099 cites W2016758434 @default.
- W2016336099 cites W2020618973 @default.
- W2016336099 cites W2021039283 @default.
- W2016336099 cites W2021061739 @default.
- W2016336099 cites W2022075858 @default.
- W2016336099 cites W2022164794 @default.
- W2016336099 cites W2022602759 @default.
- W2016336099 cites W2023909084 @default.
- W2016336099 cites W2024119753 @default.
- W2016336099 cites W2024498737 @default.
- W2016336099 cites W2025130486 @default.
- W2016336099 cites W2026674234 @default.
- W2016336099 cites W2027074304 @default.
- W2016336099 cites W2028573455 @default.
- W2016336099 cites W2028850300 @default.
- W2016336099 cites W2030061265 @default.
- W2016336099 cites W2030720135 @default.
- W2016336099 cites W2031138577 @default.
- W2016336099 cites W2032074009 @default.
- W2016336099 cites W2032139930 @default.
- W2016336099 cites W2032958110 @default.
- W2016336099 cites W2033579780 @default.
- W2016336099 cites W2033674902 @default.
- W2016336099 cites W2036177953 @default.
- W2016336099 cites W2036720692 @default.
- W2016336099 cites W2036908296 @default.
- W2016336099 cites W2037112738 @default.
- W2016336099 cites W2037568194 @default.
- W2016336099 cites W2038337878 @default.
- W2016336099 cites W2038986435 @default.
- W2016336099 cites W2039403847 @default.
- W2016336099 cites W2039993580 @default.