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• W2016336502 abstract "Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone involved in a number of biological actions in humans and rodents, but its effects on renal tissue have not yet been fully understood. The aim of this study is to assess the effect of DHEA treatment on diabetic rats, mainly in relation to renal function and metabolism. Diabetic rats were treated with subcutaneous injections of a 10mg/kg dose of DHEA diluted in oil. Plasma glucose and creatinine, in addition to urine creatinine, were quantified espectophotometrically. Glucose uptake and oxidation were quantified using radioactive glucose, the urinary Transforming Growth Factor β(1) (TGF-β(1)) was assessed by enzyme immunoassay, and the total glutathione in the renal tissue was also measured. The diabetic rats displayed higher levels of glycemia, and DHEA treatment reduced hyperglycemia. Plasmatic creatinine levels were higher in the diabetic rats treated with DHEA, while creatinine clearance was lower. Glucose uptake and oxidation were lower in the renal medulla of the diabetic rats treated with DHEA, and urinary TGF-β(1), as well as total gluthatione levels, were higher in the diabetic rats treated with DHEA. DHEA treatment was not beneficial to renal tissue, since it reduced the glomerular filtration rate and renal medulla metabolism, while increasing the urinary excretion of TGF-β(1) and the compensatory response by the glutathione system, probably due to a mechanism involving a pro-oxidant action or a pro-fibrotic effect of this androgen or its derivatives. In conclusion, this study reports that DHEA treatment may be harmful to renal tissue, but the mechanisms of this action have not yet been fully understood." @default.
• W2016336502 created "2016-06-24" @default.
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• W2016336502 date "2011-05-01" @default.
• W2016336502 modified "2023-09-30" @default.
• W2016336502 title "The effect of dehydroepiandrosterone (DHEA) on renal function and metabolism in diabetic rats" @default.
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• W2016336502 cites W1559717659 @default.
• W2016336502 cites W1567085508 @default.
• W2016336502 cites W1963864987 @default.
• W2016336502 cites W1964294020 @default.
• W2016336502 cites W1965634002 @default.
• W2016336502 cites W1969815012 @default.
• W2016336502 cites W1974115143 @default.
• W2016336502 cites W1974814803 @default.
• W2016336502 cites W1977229794 @default.
• W2016336502 cites W1981091899 @default.
• W2016336502 cites W1986480120 @default.
• W2016336502 cites W1989630160 @default.
• W2016336502 cites W1993173047 @default.
• W2016336502 cites W1994885783 @default.
• W2016336502 cites W1997807118 @default.
• W2016336502 cites W1997934348 @default.
• W2016336502 cites W2000389046 @default.
• W2016336502 cites W2008452948 @default.
• W2016336502 cites W2014829925 @default.
• W2016336502 cites W2016847030 @default.
• W2016336502 cites W2025463060 @default.
• W2016336502 cites W2025904708 @default.
• W2016336502 cites W2028309001 @default.
• W2016336502 cites W2031564330 @default.
• W2016336502 cites W2033753222 @default.
• W2016336502 cites W2035880594 @default.
• W2016336502 cites W2040961193 @default.
• W2016336502 cites W2042399960 @default.
• W2016336502 cites W2052145135 @default.
• W2016336502 cites W2053347111 @default.
• W2016336502 cites W2053745242 @default.
• W2016336502 cites W2054376239 @default.
• W2016336502 cites W2055116762 @default.
• W2016336502 cites W2069054372 @default.
• W2016336502 cites W2073762934 @default.
• W2016336502 cites W2075754126 @default.
• W2016336502 cites W2077212501 @default.
• W2016336502 cites W2077668001 @default.
• W2016336502 cites W2084904225 @default.
• W2016336502 cites W2087742312 @default.
• W2016336502 cites W2090340551 @default.
• W2016336502 cites W2096438273 @default.
• W2016336502 cites W2104976710 @default.
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• W2016336502 cites W2131757862 @default.
• W2016336502 cites W2133378345 @default.
• W2016336502 cites W2139191414 @default.
• W2016336502 cites W2144710144 @default.
• W2016336502 cites W2149598530 @default.
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• W2016336502 cites W2162289848 @default.
• W2016336502 cites W2163056783 @default.
• W2016336502 cites W2165325650 @default.
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• W2016336502 doi "https://doi.org/10.1016/j.steroids.2011.02.006" @default.
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