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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016336737> ?p ?o ?g. }

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• W2016336737 abstract "The obligate intracellular parasite Toxoplasma gondii strikes a subtle balance with the host immune system that not only prevents host death but also promotes parasite persistence. Although being enclosed within a parasitophorous vacuole, the parasite actively interfaces with host cell signaling pathways, thereby directing host cell responses. To this end, T. gondii delivers effector proteins into the host cell that co-opt host transcription factors and eventually modulate gene expression. Aside from the secretory Rhoptry organelles initially described as the main source of such effectors, Dense Granules are now recognized as critical in delivering products that remain confined at the vacuolar space or traffic beyond the vacuole membrane to the host cell nucleus and contribute to rewire host gene expression. This review highlights the latest breakthroughs in T. gondii effector discovery and their modus operandi during infection." @default.
• W2016336737 created "2016-06-24" @default.
• W2016336737 creator A5039009013 @default.
• W2016336737 creator A5040984498 @default.
• W2016336737 date "2015-08-01" @default.
• W2016336737 modified "2023-10-13" @default.
• W2016336737 title "Toxoplasma 's ways of manipulating the host transcriptome via secreted effectors" @default.
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• W2016336737 doi "https://doi.org/10.1016/j.mib.2015.04.003" @default.
• W2016336737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25912924" @default.
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