FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016336988> ?p ?o ?g. }

• W2016336988 endingPage "141" @default.
• W2016336988 startingPage "129" @default.
• W2016336988 abstract "There are conflicting results on the function of 5-HT in anxiety and depression. To reconcile this evidence, Deakin and Graeff have suggested that the ascending 5-HT pathway that originates in the dorsal raphe nucleus (DRN) and innervates the amygdala and frontal cortex facilitates conditioned fear, while the DRN-periventricular pathway innervating the periventricular and periaqueductal gray matter inhibits inborn fight/flight reactions to impending danger, pain, or asphyxia. To study the role of the DRN 5-HT system in anxiety, we microinjected 8-OH-DPAT into the DRN to inhibit 5-HT release. This treatment impaired inhibitory avoidance (conditioned fear) without affecting one-way escape (unconditioned fear) in the elevated T-maze, a new animal model of anxiety. We also applied three drug treatments that increase 5-HT release from DRN terminals: 1) intra-DRN microinjection of the benzodiazepine inverse agonist FG 4172, 2) intra-DRN microinjection of the excitatory amino acid kainic acid, and 3) intraperitoneal injection of the 5-HT releaser and uptake blocker d-fenfluramine. All treatments enhanced inhibitory avoidance in the T-maze. d-Fenfluramine and intra-DRN kainate also decreased one-way escape. In healthy volunteers, d-fenfluramine and the 5-HT agonist mCPP (mainly 5-HT2C) increased, while the antagonists ritanserin (5-HT2A2C) and SR 46349B (5-HT2A) decreased skin conductance responses to an aversively conditioned stimulus (tone). In addition, d-fenfluramine decreased, whereas ritanserin increased subjective anxiety induced by simulated public speaking, thought to represent unconditioned anxiety. Overall, these results are compatible with the above hypothesis. Deakin and Graeff have suggested that the pathway connecting the median raphe nucleus (MRN) to the dorsal hippocampus promotes resistance to chronic, unavoidable stress. In the present study, we found that 24 h after electrolytic lesion of the rat MRN glandular gastric ulcers occurred, and the immune response to the mitogen concanavalin A was depressed. Seven days after the same lesion, the ulcerogenic effect of restraint was enhanced. Microinjection of 8-OH-DPAT, the nonselective agonist 5-MeO-DMT, or the 5-HT uptake inhibitor zimelidine into the dorsal hippocampus immediately after 2 h of restraint reversed the deficits of open arm exploration in the elevated plus-maze, measured 24 h after restraint. The effect of the two last drugs was antagonized by WAY-100135, a selective 5-HT1A receptor antagonist. These results are compatible with the hypothesis that the MRN-dorsal hippocampus 5-HT system attenuates stress by facilitation of hippocampal 5-HT1A-mediated neurotransmission. Clinical implications of these results are discussed, especially with regard to panic disorder and depression." @default.
• W2016336988 created "2016-06-24" @default.
• W2016336988 creator A5005642091 @default.
• W2016336988 creator A5058457121 @default.
• W2016336988 creator A5063297653 @default.
• W2016336988 creator A5064528266 @default.
• W2016336988 date "1996-05-01" @default.
• W2016336988 modified "2023-10-16" @default.
• W2016336988 title "Role of 5-HT in stress, anxiety, and depression" @default.
• W2016336988 cites W1480003601 @default.
• W2016336988 cites W1662999323 @default.
• W2016336988 cites W1963502875 @default.
• W2016336988 cites W1969887276 @default.
• W2016336988 cites W1971472774 @default.
• W2016336988 cites W1972400180 @default.
• W2016336988 cites W1973285360 @default.
• W2016336988 cites W1976336543 @default.
• W2016336988 cites W1978402439 @default.
• W2016336988 cites W1979050991 @default.
• W2016336988 cites W1981611014 @default.
• W2016336988 cites W1986592983 @default.
• W2016336988 cites W1991954368 @default.
• W2016336988 cites W1993015131 @default.
• W2016336988 cites W1994121585 @default.
• W2016336988 cites W1997400956 @default.
• W2016336988 cites W1997880998 @default.
• W2016336988 cites W1999445315 @default.
• W2016336988 cites W2000300447 @default.
• W2016336988 cites W2001446601 @default.
• W2016336988 cites W2002924011 @default.
• W2016336988 cites W2003125564 @default.
• W2016336988 cites W2006002598 @default.
• W2016336988 cites W2006671986 @default.
• W2016336988 cites W2007890963 @default.
• W2016336988 cites W2008175050 @default.
• W2016336988 cites W2012812685 @default.
• W2016336988 cites W2013029069 @default.
• W2016336988 cites W2013584337 @default.
• W2016336988 cites W2013600778 @default.
• W2016336988 cites W2013990078 @default.
• W2016336988 cites W2018680730 @default.
• W2016336988 cites W2020184819 @default.
• W2016336988 cites W2024295917 @default.
• W2016336988 cites W2024459358 @default.
• W2016336988 cites W2026645313 @default.
• W2016336988 cites W2032888432 @default.
• W2016336988 cites W2033967523 @default.
• W2016336988 cites W2034359560 @default.
• W2016336988 cites W2034694738 @default.
• W2016336988 cites W2035581455 @default.
• W2016336988 cites W2038032637 @default.
• W2016336988 cites W2041195576 @default.
• W2016336988 cites W2041561931 @default.
• W2016336988 cites W2043567599 @default.
• W2016336988 cites W2043636380 @default.
• W2016336988 cites W2047105913 @default.
• W2016336988 cites W2047193867 @default.
• W2016336988 cites W2048283236 @default.
• W2016336988 cites W2052225153 @default.
• W2016336988 cites W2052459220 @default.
• W2016336988 cites W2052463276 @default.
• W2016336988 cites W2055028181 @default.
• W2016336988 cites W2055974590 @default.
• W2016336988 cites W2056575770 @default.
• W2016336988 cites W2061733755 @default.
• W2016336988 cites W2062815987 @default.
• W2016336988 cites W2063436217 @default.
• W2016336988 cites W2064742857 @default.
• W2016336988 cites W2066973622 @default.
• W2016336988 cites W2068168122 @default.
• W2016336988 cites W2070051797 @default.
• W2016336988 cites W2071033140 @default.
• W2016336988 cites W2072447647 @default.
• W2016336988 cites W2073629474 @default.
• W2016336988 cites W2073866710 @default.
• W2016336988 cites W2076456411 @default.
• W2016336988 cites W2078829522 @default.
• W2016336988 cites W2079495255 @default.
• W2016336988 cites W2080649078 @default.
• W2016336988 cites W2082517699 @default.
• W2016336988 cites W2085272519 @default.
• W2016336988 cites W2090912155 @default.
• W2016336988 cites W2098553579 @default.
• W2016336988 cites W2116437606 @default.
• W2016336988 cites W2137950391 @default.
• W2016336988 cites W2138426466 @default.
• W2016336988 cites W2146335796 @default.
• W2016336988 cites W2148608081 @default.
• W2016336988 cites W2150337629 @default.
• W2016336988 cites W2155404687 @default.
• W2016336988 cites W2319666608 @default.
• W2016336988 cites W2413281882 @default.
• W2016336988 cites W2414031008 @default.
• W2016336988 cites W2468511254 @default.
• W2016336988 cites W4235297070 @default.
• W2016336988 cites W4236165522 @default.
• W2016336988 doi "https://doi.org/10.1016/0091-3057(95)02135-3" @default.
• W2016336988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8728550" @default.

• next