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- W2016339097 abstract "Melanotan-II (1) is a cyclic heptapeptide analogue of α-melanocyte-stimulating hormone (α-MSH) which tans the skin and is currently being evaluated for the prevention of sunlight-induced skin cancers. The dissociation constants of 1were determined using potentiometric titration and ultraviolet spectrophotometry. The pK a 1, (histidine) and pK a 2(arginine) were estimated to be 6.54 and 11.72, respectively. The apparent partition coefficient (PC) was measured at three pH values using both n-octanol and isooctane as the nonpolar phase. The PC(octanol) and Δlog PC at pH 7.35 were 2.82 and 1.05, respectively. These data, together with the observance of a bioavailability of 4.6% in the rat, indicate that 1may be a suitable candidate for oral delivery. The data presented here are useful in developing an appropriate dosage form for 1." @default.
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- W2016339097 date "1994-08-01" @default.
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- W2016339097 title "Preformulation Studies with Melanotan-II: A Potential Skin Cancer Chemopreventive Peptide" @default.
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- W2016339097 doi "https://doi.org/10.1002/jps.2600830805" @default.
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