Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016340010> ?p ?o ?g. }
- W2016340010 endingPage "404" @default.
- W2016340010 startingPage "398" @default.
- W2016340010 abstract "Among the growing family of ribosomally synthesized, post-translationally modified peptides, particularly intriguing are class III lanthipeptides containing the triamino acid labionin. In the course of a screening program aimed at finding bacterial cell wall inhibitors, we discovered a new lanthipeptide produced by an Actinoplanes sp. The molecule, designated NAI-112, consists of 22 amino acids and contains an N-terminal labionin and a C-terminal methyl-labionin. Unique among lanthipeptides, it carries a 6-deoxyhexose moiety N-linked to a tryptophan residue. Consistently, the corresponding gene cluster encodes, in addition to the LanKC enzyme characteristic of this lanthipeptide class, a glycosyl transferase. Despite possessing weak antibacterial activity, NAI-112 is effective in experimental models of nociceptive pain, reducing pain symptoms in mice in both the formalin and the chronic constriction injury tests. Thus, NAI-112 represents, after the labyrinthopeptins, the second example of a lanthipeptide effective against nociceptive pain." @default.
- W2016340010 created "2016-06-24" @default.
- W2016340010 creator A5022838040 @default.
- W2016340010 creator A5023227212 @default.
- W2016340010 creator A5031213755 @default.
- W2016340010 creator A5037632094 @default.
- W2016340010 creator A5047405127 @default.
- W2016340010 creator A5050965877 @default.
- W2016340010 creator A5052141168 @default.
- W2016340010 creator A5058543694 @default.
- W2016340010 creator A5060650777 @default.
- W2016340010 creator A5060871332 @default.
- W2016340010 creator A5069595808 @default.
- W2016340010 creator A5072331809 @default.
- W2016340010 creator A5072981913 @default.
- W2016340010 creator A5085300503 @default.
- W2016340010 creator A5090133195 @default.
- W2016340010 date "2013-11-20" @default.
- W2016340010 modified "2023-10-01" @default.
- W2016340010 title "A Glycosylated, Labionin-Containing Lanthipeptide with Marked Antinociceptive Activity" @default.
- W2016340010 cites W1481209183 @default.
- W2016340010 cites W197482517 @default.
- W2016340010 cites W1976080759 @default.
- W2016340010 cites W1980897478 @default.
- W2016340010 cites W1981961272 @default.
- W2016340010 cites W1986299243 @default.
- W2016340010 cites W1991132716 @default.
- W2016340010 cites W1992864393 @default.
- W2016340010 cites W2003859649 @default.
- W2016340010 cites W2014007136 @default.
- W2016340010 cites W2026042628 @default.
- W2016340010 cites W2043300583 @default.
- W2016340010 cites W2052519363 @default.
- W2016340010 cites W2058020736 @default.
- W2016340010 cites W2068460650 @default.
- W2016340010 cites W2072516618 @default.
- W2016340010 cites W2079504994 @default.
- W2016340010 cites W2080008075 @default.
- W2016340010 cites W2101169552 @default.
- W2016340010 cites W2104669367 @default.
- W2016340010 cites W2149855043 @default.
- W2016340010 cites W2150328215 @default.
- W2016340010 cites W2161167549 @default.
- W2016340010 cites W2162854463 @default.
- W2016340010 cites W2171165413 @default.
- W2016340010 cites W2330503377 @default.
- W2016340010 cites W2405005113 @default.
- W2016340010 cites W2405300865 @default.
- W2016340010 cites W2950983061 @default.
- W2016340010 doi "https://doi.org/10.1021/cb400692w" @default.
- W2016340010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24191663" @default.
- W2016340010 hasPublicationYear "2013" @default.
- W2016340010 type Work @default.
- W2016340010 sameAs 2016340010 @default.
- W2016340010 citedByCount "81" @default.
- W2016340010 countsByYear W20163400102014 @default.
- W2016340010 countsByYear W20163400102015 @default.
- W2016340010 countsByYear W20163400102016 @default.
- W2016340010 countsByYear W20163400102017 @default.
- W2016340010 countsByYear W20163400102018 @default.
- W2016340010 countsByYear W20163400102019 @default.
- W2016340010 countsByYear W20163400102020 @default.
- W2016340010 countsByYear W20163400102021 @default.
- W2016340010 countsByYear W20163400102022 @default.
- W2016340010 countsByYear W20163400102023 @default.
- W2016340010 crossrefType "journal-article" @default.
- W2016340010 hasAuthorship W2016340010A5022838040 @default.
- W2016340010 hasAuthorship W2016340010A5023227212 @default.
- W2016340010 hasAuthorship W2016340010A5031213755 @default.
- W2016340010 hasAuthorship W2016340010A5037632094 @default.
- W2016340010 hasAuthorship W2016340010A5047405127 @default.
- W2016340010 hasAuthorship W2016340010A5050965877 @default.
- W2016340010 hasAuthorship W2016340010A5052141168 @default.
- W2016340010 hasAuthorship W2016340010A5058543694 @default.
- W2016340010 hasAuthorship W2016340010A5060650777 @default.
- W2016340010 hasAuthorship W2016340010A5060871332 @default.
- W2016340010 hasAuthorship W2016340010A5069595808 @default.
- W2016340010 hasAuthorship W2016340010A5072331809 @default.
- W2016340010 hasAuthorship W2016340010A5072981913 @default.
- W2016340010 hasAuthorship W2016340010A5085300503 @default.
- W2016340010 hasAuthorship W2016340010A5090133195 @default.
- W2016340010 hasBestOaLocation W20163400102 @default.
- W2016340010 hasConcept C15490471 @default.
- W2016340010 hasConcept C170493617 @default.
- W2016340010 hasConcept C181199279 @default.
- W2016340010 hasConcept C185592680 @default.
- W2016340010 hasConcept C2776568683 @default.
- W2016340010 hasConcept C2779281246 @default.
- W2016340010 hasConcept C2780906977 @default.
- W2016340010 hasConcept C2781338088 @default.
- W2016340010 hasConcept C515207424 @default.
- W2016340010 hasConcept C55493867 @default.
- W2016340010 hasConcept C71240020 @default.
- W2016340010 hasConceptScore W2016340010C15490471 @default.
- W2016340010 hasConceptScore W2016340010C170493617 @default.
- W2016340010 hasConceptScore W2016340010C181199279 @default.
- W2016340010 hasConceptScore W2016340010C185592680 @default.
- W2016340010 hasConceptScore W2016340010C2776568683 @default.