Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016343237> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2016343237 endingPage "330" @default.
- W2016343237 startingPage "307" @default.
- W2016343237 abstract "Urinary proteins of patients with myeloma, prepared by precipitation with ammonium sulphate, have been separated by gel filtration on Sephadex G-100 after reduction and aminoethylation. Many specimens separated into a major peak of Bence Jones protein and into minor peaks of albumin, a protein tentatively identified with heavy chain and a smaller molecular weight protein corresponding to the variable portion of the corresponding Bence Jones protein. The Bence Jones protein purified by gel filtration was analyzed by electrophoresis and by peptide mapping after tryptic digestion. The peptide maps of 24 type K and 20 type L Bence Jones proteins were compared. A set of common peptides was identified in the peptide maps of the Bence Jones proteins of the same type; the common peptides of type K proteins were completely different from the common peptides of type L proteins. The patterns of distinctive peptides was compared; no similarities were found between distinctive peptides of type K and of type L proteins. Some similarities were observed in the distinctive peptides of proteins of the same type. The similarities involved in many cases peptides containing cysteine, whereas similarities in other peptides were limited. This observation suggested that the amino acid sequence around the cysteines of the variable NH2-terminal half of the Bence Jones proteins may show less variability than other sequences. A few proteins of the same type differed in all their distinctive peptides, an indication that multiple amino acid differences exist between individual Bence Jones proteins. The genetic mechanisms responsible for the variability in the amino acid sequence of the NH2-terminal half of the light chains of immunoglobulins are discussed in view of the results of the comparison by peptide mapping of the Bence Jones proteins." @default.
- W2016343237 created "2016-06-24" @default.
- W2016343237 creator A5026911306 @default.
- W2016343237 creator A5066601149 @default.
- W2016343237 date "1966-09-01" @default.
- W2016343237 modified "2023-09-27" @default.
- W2016343237 title "A STUDY OF IMMUNOGLOBULIN STRUCTURE" @default.
- W2016343237 cites W1971684377 @default.
- W2016343237 cites W1975122842 @default.
- W2016343237 cites W1975514861 @default.
- W2016343237 cites W1986989177 @default.
- W2016343237 cites W1989170328 @default.
- W2016343237 cites W1991367639 @default.
- W2016343237 cites W2004060933 @default.
- W2016343237 cites W2008296247 @default.
- W2016343237 cites W2012691876 @default.
- W2016343237 cites W2019644269 @default.
- W2016343237 cites W2033962119 @default.
- W2016343237 cites W2042390410 @default.
- W2016343237 cites W2049087409 @default.
- W2016343237 cites W2058772523 @default.
- W2016343237 cites W2091637599 @default.
- W2016343237 cites W2094719909 @default.
- W2016343237 cites W2233812595 @default.
- W2016343237 cites W2340057434 @default.
- W2016343237 cites W4243044389 @default.
- W2016343237 doi "https://doi.org/10.1084/jem.124.3.307" @default.
- W2016343237 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2138226" @default.
- W2016343237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5924372" @default.
- W2016343237 hasPublicationYear "1966" @default.
- W2016343237 type Work @default.
- W2016343237 sameAs 2016343237 @default.
- W2016343237 citedByCount "25" @default.
- W2016343237 crossrefType "journal-article" @default.
- W2016343237 hasAuthorship W2016343237A5026911306 @default.
- W2016343237 hasAuthorship W2016343237A5066601149 @default.
- W2016343237 hasBestOaLocation W20163432371 @default.
- W2016343237 hasConcept C104317684 @default.
- W2016343237 hasConcept C153911025 @default.
- W2016343237 hasConcept C159654299 @default.
- W2016343237 hasConcept C163994747 @default.
- W2016343237 hasConcept C167625842 @default.
- W2016343237 hasConcept C181199279 @default.
- W2016343237 hasConcept C185592680 @default.
- W2016343237 hasConcept C188758523 @default.
- W2016343237 hasConcept C193363816 @default.
- W2016343237 hasConcept C2779281246 @default.
- W2016343237 hasConcept C36394416 @default.
- W2016343237 hasConcept C515207424 @default.
- W2016343237 hasConcept C52697466 @default.
- W2016343237 hasConcept C54355233 @default.
- W2016343237 hasConcept C55493867 @default.
- W2016343237 hasConcept C86803240 @default.
- W2016343237 hasConceptScore W2016343237C104317684 @default.
- W2016343237 hasConceptScore W2016343237C153911025 @default.
- W2016343237 hasConceptScore W2016343237C159654299 @default.
- W2016343237 hasConceptScore W2016343237C163994747 @default.
- W2016343237 hasConceptScore W2016343237C167625842 @default.
- W2016343237 hasConceptScore W2016343237C181199279 @default.
- W2016343237 hasConceptScore W2016343237C185592680 @default.
- W2016343237 hasConceptScore W2016343237C188758523 @default.
- W2016343237 hasConceptScore W2016343237C193363816 @default.
- W2016343237 hasConceptScore W2016343237C2779281246 @default.
- W2016343237 hasConceptScore W2016343237C36394416 @default.
- W2016343237 hasConceptScore W2016343237C515207424 @default.
- W2016343237 hasConceptScore W2016343237C52697466 @default.
- W2016343237 hasConceptScore W2016343237C54355233 @default.
- W2016343237 hasConceptScore W2016343237C55493867 @default.
- W2016343237 hasConceptScore W2016343237C86803240 @default.
- W2016343237 hasIssue "3" @default.
- W2016343237 hasLocation W20163432371 @default.
- W2016343237 hasLocation W20163432372 @default.
- W2016343237 hasLocation W20163432373 @default.
- W2016343237 hasLocation W20163432374 @default.
- W2016343237 hasOpenAccess W2016343237 @default.
- W2016343237 hasPrimaryLocation W20163432371 @default.
- W2016343237 hasRelatedWork W117434477 @default.
- W2016343237 hasRelatedWork W1540438504 @default.
- W2016343237 hasRelatedWork W1987516645 @default.
- W2016343237 hasRelatedWork W2013628175 @default.
- W2016343237 hasRelatedWork W2021206868 @default.
- W2016343237 hasRelatedWork W2086782494 @default.
- W2016343237 hasRelatedWork W2091998837 @default.
- W2016343237 hasRelatedWork W2377337883 @default.
- W2016343237 hasRelatedWork W2397316053 @default.
- W2016343237 hasRelatedWork W4321835912 @default.
- W2016343237 hasVolume "124" @default.
- W2016343237 isParatext "false" @default.
- W2016343237 isRetracted "false" @default.
- W2016343237 magId "2016343237" @default.
- W2016343237 workType "article" @default.