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• W2016348314 abstract "A double-blind, placebo-controlled study was done to evaluate the efficacy of an alpha interferon preparation in 128 patients with recurrent genital herpes. The preparation containing 105 or 107 U alpha interferon with nonoxynol 9 in a cream base (Exovir-HZ) was applied three times daily for 5 days. The treatment did not cause any adverse reactions. Patients treated with either interferon concentration became negative for viral culture at a faster rate than placebo recipients. The end of new lesion formation, scabbing, and the healing of lesions were all superior in patients treated with 105 U to those treated with 107 U interferon. End of new lesion formation and scabbing were also statistically different in patients treated with 107 U from those patients treated with placebo. Results suggest that topical interferon might be useful in relieving symptoms of severe cases of genital herpes. A double-blind, placebo-controlled study was done to evaluate the efficacy of an alpha interferon preparation in 128 patients with recurrent genital herpes. The preparation containing 105 or 107 U alpha interferon with nonoxynol 9 in a cream base (Exovir-HZ) was applied three times daily for 5 days. The treatment did not cause any adverse reactions. Patients treated with either interferon concentration became negative for viral culture at a faster rate than placebo recipients. The end of new lesion formation, scabbing, and the healing of lesions were all superior in patients treated with 105 U to those treated with 107 U interferon. End of new lesion formation and scabbing were also statistically different in patients treated with 107 U from those patients treated with placebo. Results suggest that topical interferon might be useful in relieving symptoms of severe cases of genital herpes." @default.
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• W2016348314 date "1986-11-01" @default.
• W2016348314 modified "2023-09-29" @default.
• W2016348314 title "Treatment of recurrent genital herpes with topical alpha interferon gel combined with nonoxynol 9" @default.
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• W2016348314 doi "https://doi.org/10.1016/s0190-9622(86)70262-4" @default.
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