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- W2016350464 abstract "Abstract The aims of this study were to observe the changes in antioxidative defense enzymes and renal morphology after 7,12‐dimethyl‐benz[ a ]anthracene (7,12‐DMBA) administration in mice and to investigate the possible protective effects of melatonin against 7,12‐DMBA‐induced renal damage in comparison with vitamin E + selenium (vit E + Se). Forty female mice were divided into four groups: control, DMBA, DMBA + vit E + Se and DMBA + melatonin. In the DMBA group, mice were given injections of 7,12‐DMBA (20 mg/kg). DMBA + vit E + Se group mice received injections of 7,12‐DMBA + vit E + Se (20 mg/kg + 90 mg/kg + 1.8 μ g/kg). In the melatonin group, mice were given injections of 7,12‐DMBA + melatonin (20 mg/kg + 4.2 mg/kg). The experiment lasted for 21 days. Mice were killed and the kidneys were taken for enzyme analyses and histologic examination. Catalase (CAT) and glutathione peroxidase (GSH‐Px) activities were found significantly decreased in the DMBA group and in the DMBA + vit E + Se group when compared with the control group ( P < 0.05), whereas CAT and GSH‐Px activities were found significantly elevated in the DMBA + melatonin group when compared with the control ( P < 0.05) and the DMBA group ( P < 0.01). Exposure to DMBA resulted in tubular alterations in renal cortex. Morphometric analysis revealed proximal and distal tubular damage ( P < 0.05). These alterations were found to be prevented by melatonin but not with vit E + Se administration. These results reveal that melatonin stimulates CAT and GSH‐Px activities and prevents renal injury better than vit E + Se combination in mice kidneys." @default.
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- W2016350464 date "2006-07-06" @default.
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- W2016350464 title "The effect of melatonin on 7,12-dimethyl-benz[a]anthracene injury in comparison with vitamin E + selenium in mouse kidneys" @default.
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- W2016350464 doi "https://doi.org/10.1111/j.1472-8206.2006.00419.x" @default.
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