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- W2016352453 endingPage "568" @default.
- W2016352453 startingPage "558" @default.
- W2016352453 abstract "Mitochondrial disorders are a heterogeneous group of diseases affecting different organs (brain, muscle, liver, and heart), and the severity of the disease is highly variable. The chronicity and heterogeneity, both clinically and genetically, means that many patients require surveillance follow-up over their lifetime, often involving multiple disciplines. Although our understanding of the genetic defects and their pathological impact underlying mitochondrial diseases has increased over the past decade, this has not been paralleled with regards to treatment. Currently, no definitive pharmacological treatment exists for patients with mitochondrial dysfunction, except for patients with primary deficiency of coenzyme Q10. Pharmacological and nonpharmacological treatments increasingly being investigated include ketogenic diet, exercise, and gene therapy. Management is aimed primarily at minimizing disability, preventing complications, and providing prognostic information and genetic counseling based on current best practice. Here, we evaluate therapies used previously and review current and future treatment modalities for both adults and children with mitochondrial disease." @default.
- W2016352453 created "2016-06-24" @default.
- W2016352453 creator A5006400472 @default.
- W2016352453 creator A5013583757 @default.
- W2016352453 creator A5036864941 @default.
- W2016352453 date "2008-10-01" @default.
- W2016352453 modified "2023-09-25" @default.
- W2016352453 title "How can we treat mitochondrial encephalomyopathies? approaches to therapy" @default.
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