FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016352485> ?p ?o ?g. }

• W2016352485 endingPage "596" @default.
• W2016352485 startingPage "592" @default.
• W2016352485 abstract "Dendritic epidermal T cells (DETC), which are skin-specific members of the tissue-resident gamma delta T-cell family, are characterized by their potential to kill selected tumor targets by a non-major histocompatibility complex (MHC)-restricted mechanism. We have recently identified a new receptor molecule, 2B4, that appears to be associated with non-MHC-restricted recognition of tumor targets by natural killer cells. The purpose of this study was to determine whether DETC express 2B4 molecules, and, if so, to assess their functional roles in DETC-mediated killing of tumor targets. Short-term DETC lines as well as DETC freshly procured from skin expressed surface 2B4, as detected with a specific monoclonal antibody. Removal of interleukin (IL)-2 from DETC cultures caused substantial reduction in 2B4 expression levels as well as a reduction in cytotoxic capacity against YAC-1 targets in a standard 51Cr-release assay. Conversely, exposure to IL-2, but not to IL-7, elevated both 2B4 expression and cytotoxicity. To assess the functional roles played by surface 2B4, we pretreated DETC lines with anti-2B4 antibody and then tested for their killing potential. Anti-2B4, but not the control antibody, augmented their capacity to lyse YAC-1 targets (51Cr-release assays) and to disrupt the monolayers of Pam-212-transformed keratinocytes (visual assessment). Thus, we conclude that DETC express, in an IL-2-dependent manner, 2B4 molecules, which may play a unique role in the killing of skin-derived tumors." @default.
• W2016352485 created "2016-06-24" @default.
• W2016352485 creator A5007880115 @default.
• W2016352485 creator A5041317291 @default.
• W2016352485 creator A5048300448 @default.
• W2016352485 creator A5049362067 @default.
• W2016352485 creator A5067008857 @default.
• W2016352485 creator A5088293109 @default.
• W2016352485 date "1995-10-01" @default.
• W2016352485 modified "2023-09-23" @default.
• W2016352485 title "2B4, a New Member of the Immunoglobulin Gene Superfamily, Is Expressed on Murine Dendritic Epidermal T Cells and Plays a Functional Role in Their Killing of Skin Tumors" @default.
• W2016352485 cites W1497874333 @default.
• W2016352485 cites W1538092336 @default.
• W2016352485 cites W1549867593 @default.
• W2016352485 cites W1558030894 @default.
• W2016352485 cites W1584767304 @default.
• W2016352485 cites W1662706554 @default.
• W2016352485 cites W1757657519 @default.
• W2016352485 cites W1887563241 @default.
• W2016352485 cites W1965130012 @default.
• W2016352485 cites W1979417369 @default.
• W2016352485 cites W1992866275 @default.
• W2016352485 cites W2014012740 @default.
• W2016352485 cites W2026405673 @default.
• W2016352485 cites W2040538412 @default.
• W2016352485 cites W2041542311 @default.
• W2016352485 cites W2048848271 @default.
• W2016352485 cites W2084023405 @default.
• W2016352485 cites W2087861263 @default.
• W2016352485 cites W2154503489 @default.
• W2016352485 cites W2269739474 @default.
• W2016352485 cites W2339882653 @default.
• W2016352485 doi "https://doi.org/10.1111/1523-1747.ep12323533" @default.
• W2016352485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7561164" @default.
• W2016352485 hasPublicationYear "1995" @default.
• W2016352485 type Work @default.
• W2016352485 sameAs 2016352485 @default.
• W2016352485 citedByCount "64" @default.
• W2016352485 countsByYear W20163524852013 @default.
• W2016352485 countsByYear W20163524852014 @default.
• W2016352485 countsByYear W20163524852015 @default.
• W2016352485 countsByYear W20163524852016 @default.
• W2016352485 countsByYear W20163524852017 @default.
• W2016352485 countsByYear W20163524852018 @default.
• W2016352485 countsByYear W20163524852019 @default.
• W2016352485 countsByYear W20163524852020 @default.
• W2016352485 countsByYear W20163524852021 @default.
• W2016352485 countsByYear W20163524852022 @default.
• W2016352485 crossrefType "journal-article" @default.
• W2016352485 hasAuthorship W2016352485A5007880115 @default.
• W2016352485 hasAuthorship W2016352485A5041317291 @default.
• W2016352485 hasAuthorship W2016352485A5048300448 @default.
• W2016352485 hasAuthorship W2016352485A5049362067 @default.
• W2016352485 hasAuthorship W2016352485A5067008857 @default.
• W2016352485 hasAuthorship W2016352485A5088293109 @default.
• W2016352485 hasBestOaLocation W20163524851 @default.
• W2016352485 hasConcept C109316439 @default.
• W2016352485 hasConcept C153911025 @default.
• W2016352485 hasConcept C154317977 @default.
• W2016352485 hasConcept C159654299 @default.
• W2016352485 hasConcept C202751555 @default.
• W2016352485 hasConcept C203014093 @default.
• W2016352485 hasConcept C207936829 @default.
• W2016352485 hasConcept C502942594 @default.
• W2016352485 hasConcept C542903549 @default.
• W2016352485 hasConcept C54355233 @default.
• W2016352485 hasConcept C86803240 @default.
• W2016352485 hasConcept C8891405 @default.
• W2016352485 hasConcept C95444343 @default.
• W2016352485 hasConceptScore W2016352485C109316439 @default.
• W2016352485 hasConceptScore W2016352485C153911025 @default.
• W2016352485 hasConceptScore W2016352485C154317977 @default.
• W2016352485 hasConceptScore W2016352485C159654299 @default.
• W2016352485 hasConceptScore W2016352485C202751555 @default.
• W2016352485 hasConceptScore W2016352485C203014093 @default.
• W2016352485 hasConceptScore W2016352485C207936829 @default.
• W2016352485 hasConceptScore W2016352485C502942594 @default.
• W2016352485 hasConceptScore W2016352485C542903549 @default.
• W2016352485 hasConceptScore W2016352485C54355233 @default.
• W2016352485 hasConceptScore W2016352485C86803240 @default.
• W2016352485 hasConceptScore W2016352485C8891405 @default.
• W2016352485 hasConceptScore W2016352485C95444343 @default.
• W2016352485 hasIssue "4" @default.
• W2016352485 hasLocation W20163524851 @default.
• W2016352485 hasLocation W20163524852 @default.
• W2016352485 hasOpenAccess W2016352485 @default.
• W2016352485 hasPrimaryLocation W20163524851 @default.
• W2016352485 hasRelatedWork W1892306976 @default.
• W2016352485 hasRelatedWork W2024203776 @default.
• W2016352485 hasRelatedWork W2029611001 @default.
• W2016352485 hasRelatedWork W2041811834 @default.
• W2016352485 hasRelatedWork W2067077431 @default.
• W2016352485 hasRelatedWork W2368460920 @default.
• W2016352485 hasRelatedWork W2380360044 @default.
• W2016352485 hasRelatedWork W2443772760 @default.
• W2016352485 hasRelatedWork W3180719608 @default.
• W2016352485 hasRelatedWork W773424912 @default.
• W2016352485 hasVolume "105" @default.

• next