Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016352987> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2016352987 abstract "We address an issue of detecting a switching mechanism in gene expression, where two genes are positively correlated for one experimental condition while they are negatively correlated for another. We compare the performance of existing methods for this issue, roughly divided into two types: interaction test (IT) and the difference of correlation coefficients. Interaction test, currently a standard approach for detecting epistasis in genetics, is the log-likelihood ratio test between two logistic regressions with/without an interaction term, resulting in checking the strength of interaction between two genes. On the other hand, two correlation coefficients can be computed for two experimental conditions and the difference of them shows the alteration of expression trends in a more straightforward manner. In our experiments, we tested three different types of correlation coefficients: Pearson, Spearman and a midcorrelation (biweight midcorrelation). The experiment was performed by using ~ 2.3 × 10(9) combinations selected out of the GEO (Gene Expression Omnibus) database. We sorted all combinations according to the p-values of IT or by the absolute values of the difference of correlation coefficients and then visually evaluated the top ranked combinations in terms of the switching mechanism. The result showed that 1) combinations detected by IT included non-switching combinations and 2) Pearson was affected by outliers easily while Spearman and the midcorrelation seemed likely to avoid them." @default.
- W2016352987 created "2016-06-24" @default.
- W2016352987 creator A5009745749 @default.
- W2016352987 creator A5012617043 @default.
- W2016352987 creator A5059001924 @default.
- W2016352987 creator A5070597006 @default.
- W2016352987 creator A5083977312 @default.
- W2016352987 date "2010-07-01" @default.
- W2016352987 modified "2023-09-25" @default.
- W2016352987 title "ON THE PERFORMANCE OF METHODS FOR FINDING A SWITCHING MECHANISM IN GENE EXPRESSION" @default.
- W2016352987 cites W139767586 @default.
- W2016352987 cites W2012712694 @default.
- W2016352987 cites W2069436548 @default.
- W2016352987 cites W2086132387 @default.
- W2016352987 cites W2106620396 @default.
- W2016352987 cites W2118460019 @default.
- W2016352987 cites W2121195642 @default.
- W2016352987 cites W2125354326 @default.
- W2016352987 cites W2135874888 @default.
- W2016352987 cites W2139807849 @default.
- W2016352987 cites W2139845570 @default.
- W2016352987 cites W2154362705 @default.
- W2016352987 cites W2162142896 @default.
- W2016352987 cites W2165133998 @default.
- W2016352987 cites W2203974440 @default.
- W2016352987 cites W2553645446 @default.
- W2016352987 doi "https://doi.org/10.1142/9781848166585_0006" @default.
- W2016352987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22081590" @default.
- W2016352987 hasPublicationYear "2010" @default.
- W2016352987 type Work @default.
- W2016352987 sameAs 2016352987 @default.
- W2016352987 citedByCount "1" @default.
- W2016352987 countsByYear W20163529872014 @default.
- W2016352987 crossrefType "proceedings-article" @default.
- W2016352987 hasAuthorship W2016352987A5009745749 @default.
- W2016352987 hasAuthorship W2016352987A5012617043 @default.
- W2016352987 hasAuthorship W2016352987A5059001924 @default.
- W2016352987 hasAuthorship W2016352987A5070597006 @default.
- W2016352987 hasAuthorship W2016352987A5083977312 @default.
- W2016352987 hasConcept C104317684 @default.
- W2016352987 hasConcept C105795698 @default.
- W2016352987 hasConcept C117220453 @default.
- W2016352987 hasConcept C121332964 @default.
- W2016352987 hasConcept C151956035 @default.
- W2016352987 hasConcept C159744936 @default.
- W2016352987 hasConcept C199360897 @default.
- W2016352987 hasConcept C2524010 @default.
- W2016352987 hasConcept C2780092901 @default.
- W2016352987 hasConcept C2991772755 @default.
- W2016352987 hasConcept C3018023364 @default.
- W2016352987 hasConcept C33923547 @default.
- W2016352987 hasConcept C41008148 @default.
- W2016352987 hasConcept C54355233 @default.
- W2016352987 hasConcept C55078378 @default.
- W2016352987 hasConcept C61727976 @default.
- W2016352987 hasConcept C62520636 @default.
- W2016352987 hasConcept C79337645 @default.
- W2016352987 hasConcept C86803240 @default.
- W2016352987 hasConcept C89611455 @default.
- W2016352987 hasConcept C90559484 @default.
- W2016352987 hasConceptScore W2016352987C104317684 @default.
- W2016352987 hasConceptScore W2016352987C105795698 @default.
- W2016352987 hasConceptScore W2016352987C117220453 @default.
- W2016352987 hasConceptScore W2016352987C121332964 @default.
- W2016352987 hasConceptScore W2016352987C151956035 @default.
- W2016352987 hasConceptScore W2016352987C159744936 @default.
- W2016352987 hasConceptScore W2016352987C199360897 @default.
- W2016352987 hasConceptScore W2016352987C2524010 @default.
- W2016352987 hasConceptScore W2016352987C2780092901 @default.
- W2016352987 hasConceptScore W2016352987C2991772755 @default.
- W2016352987 hasConceptScore W2016352987C3018023364 @default.
- W2016352987 hasConceptScore W2016352987C33923547 @default.
- W2016352987 hasConceptScore W2016352987C41008148 @default.
- W2016352987 hasConceptScore W2016352987C54355233 @default.
- W2016352987 hasConceptScore W2016352987C55078378 @default.
- W2016352987 hasConceptScore W2016352987C61727976 @default.
- W2016352987 hasConceptScore W2016352987C62520636 @default.
- W2016352987 hasConceptScore W2016352987C79337645 @default.
- W2016352987 hasConceptScore W2016352987C86803240 @default.
- W2016352987 hasConceptScore W2016352987C89611455 @default.
- W2016352987 hasConceptScore W2016352987C90559484 @default.
- W2016352987 hasLocation W20163529871 @default.
- W2016352987 hasLocation W20163529872 @default.
- W2016352987 hasOpenAccess W2016352987 @default.
- W2016352987 hasPrimaryLocation W20163529871 @default.
- W2016352987 hasRelatedWork W132711133 @default.
- W2016352987 hasRelatedWork W1529026127 @default.
- W2016352987 hasRelatedWork W1911095394 @default.
- W2016352987 hasRelatedWork W2016352987 @default.
- W2016352987 hasRelatedWork W2051272551 @default.
- W2016352987 hasRelatedWork W2123233148 @default.
- W2016352987 hasRelatedWork W2560331580 @default.
- W2016352987 hasRelatedWork W2969295906 @default.
- W2016352987 hasRelatedWork W3152154711 @default.
- W2016352987 hasRelatedWork W4200439127 @default.
- W2016352987 isParatext "false" @default.
- W2016352987 isRetracted "false" @default.
- W2016352987 magId "2016352987" @default.
- W2016352987 workType "article" @default.