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• W2016354735 abstract "Abstract Hypercitrullinemia (adult type) is known to be complicated by hepatocellular carcinoma at a high incidence. We have previously reported that citrulline (Cit) acts as a hepatocarcinogenesis promoter in the in vitro tumor promotion analyzing system (Hepatology 1990;11:819–823). In this report, the tumor-promoting effect of Cit was further studied in the in vivo experimental hepatocarcinogenic model using diethylnitrosamine and 2-acetylaminofluorene as initiators. The incidence rate of hyperplastic nodules in the liver was significantly higher in the phenobarbital-fed group (83.3%) and Cit-fed group (100%) than in the control group (16.7%). Enzyme-altered islands, strongly positive for γ-GTP staining, were observed in the hyperplastic nodules. The promoting effect of Cit on hepatic carcinogenesis was confirmed also in the in vivo system." @default.
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• W2016354735 date "1993-03-15" @default.
• W2016354735 modified "2023-09-25" @default.
• W2016354735 title "Study on hepatocarcinogenesis in hypercitrullinemia Promoting effect of citrulline in experimental hepatocarcinogenesis" @default.
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• W2016354735 doi "https://doi.org/10.1016/0928-4346(93)90033-c" @default.
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