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- W2016355953 abstract "Based on the notion that cerebral accumulation of certain Aβ species (unprocessed and N-terminally truncated/modified molecules) is central to the pathogenesis of Alzheimer's disease (AD) and endowed with the knowledge emerging during clinical testing of the first Alzheimer vaccine, AN1792, AFFiRiS designed a new type of AD vaccines. Rather than relying on full-length Aβ or fragments thereof, AFFITOPE vaccines use short peptides mimicking neoepitopes of Aβ as their antigenic component. The technology created to identify these peptides, termed AFFITOME-technology, concomitantly provides the basis for the multi-component safety concept realized in AFFITOPE vaccines. First, as they are non-self, AFFITOPES don't need to break tolerance typically established against self proteins. This allows the use of aluminium, the first immunological adjuvant approved for human use and, thus, exhibiting an excellent safety profile. Second, AFFITOPES applied in AD vaccines are only 6 amino acids in length, which precludes the activation of Aβ-specific autoreactive T cells. Third, the AFFITOME technology allows for controlling the specificity of the vaccine-induced antibody response focusing it on Aβ and preventing crossreactivity with APP. In a program based on two AFFITOPES, AD01 and AD02, both targeting the N-terminus of Aβ, this approach was taken all the way from concept to clinical application. Clinical phase I data on both vaccines support the safety concept inherent to the new generation of AFFITOPE AD vaccines. Further clinical testing, done by AFFiRiS, will focus on the vaccines' effects on the pathology underlying AD and their clinical activity, and, on new vaccines tackling modified and truncated Aβ species." @default.
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- W2016355953 date "2010-07-01" @default.
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- W2016355953 title "P3-447: Development of AFFITOPE vaccines for Alzheimer's disease" @default.
- W2016355953 doi "https://doi.org/10.1016/j.jalz.2010.05.1989" @default.
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