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• W2016358509 abstract "The synthesis of organo-soluble hybrid particles with a hydrophobic, α-helical polypeptide shell and silica core has been achieved by combining ring-opening polymerization and click chemistry. Alkyne end-terminated poly(γ-stearyl-α-l-glutamate) (alkyne-PSLG) was prepared by the ring-opening polymerization of the N-carboxyanhydride of γ-stearyl-α-l-glutamate using propargylamine as initiator. The molecular weight and structure of this polypeptide were characterized by GPC and MALDI, and the α-helical nature was established by 1H NMR and FTIR. Azide-functionalized silica particles (azido-silica) were prepared by the functionalization of silica particles with 3-bromopropyltrichlorosilane followed by nucleophilic substitution with sodium azide. The azide functionalization was confirmed by FTIR and XPS. Alkyne-PSLG was coupled to azido-silica by click reaction in tetrahydrofuran or toluene in the presence of pentamethyldiethylenetriamine and copper(I) bromide. Further characterization of the product using XPS, FTIR, and 1H NMR revealed that the grafted polypeptide retained its α-helical nature and formed colloidal particles that readily dispersed in organic solvents. These hydrophobic, polypeptide-functionalized particles can serve as model systems in studies of colloid dynamics and/or crystallization. They may also find use in investigations designed to model enzyme activation or the properties of hydrophobic proteins in cell membranes." @default.
• W2016358509 created "2016-06-24" @default.
• W2016358509 creator A5008746722 @default.
• W2016358509 creator A5027516563 @default.
• W2016358509 creator A5047458659 @default.
• W2016358509 creator A5084936418 @default.
• W2016358509 date "2009-11-19" @default.
• W2016358509 modified "2023-09-27" @default.
• W2016358509 title "Preparation of Organosoluble Silica−Polypeptide Particles by “Click” Chemistry" @default.
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• W2016358509 doi "https://doi.org/10.1021/ma901840n" @default.
• W2016358509 hasPublicationYear "2009" @default.
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