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- W2016358688 abstract "The status of research on γδ T cells is reviewed. Recent research shows that γδ T cells may see antigens in an immunoglobulin-like manner and that non-peptidic substance can be antigens for these cells. Considerable advances have been made in defining the immunobiology of γδ T cells, with evidence for sentinel, protective and immunoregulatory roles. Research on γδ T cells in malaria infections suggests that γδ T cells are mediators of protective immunity, most probably through the production of Th1 cytokines such as TNFα, TNFδ and IFNγ and that excessive production of such cytokines may contribute to pathology. Our data on the features of the peripheral blood γδ T cell response in humans infected with Plasmodium falciparum show that there is considerable variation between individuals in the relative expension of γδ T lymphocytes fellewing primary or secondary infection. They confirm that activation of γδ T cells occurs during P. falciparum infection and that activated cells can persist for many weeks after treatment. The possibility that γδ T cells have an immunoregulatory function in malaria infections is proposed." @default.
- W2016358688 created "2016-06-24" @default.
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- W2016358688 date "1997-02-01" @default.
- W2016358688 modified "2023-10-18" @default.
- W2016358688 title "γδ T cells: Their immunobiology and role in malaria infections" @default.
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- W2016358688 doi "https://doi.org/10.1016/s0020-7519(96)00149-x" @default.
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