Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016361601> ?p ?o ?g. }
- W2016361601 endingPage "277" @default.
- W2016361601 startingPage "271" @default.
- W2016361601 abstract "Although pituitary hormones are known to affect immune function, treated hypopituitarism is not a recognized cause of immune deficiency in humans. We set out to assess integrity of baseline and stimulated immune function in severely hypopituitary adults. Twenty-one panhypopituitary adults (group 1), on stable pituitary replacement including growth hormone, and 12 healthy volunteers (group 2) were studied. Lymphocyte subsets, pneumococcal antibody levels pre- and 1 month after polysaccharide vaccination, T cell numbers and in-vitro interferon (IFN)-gamma response were studied. There were no significant differences in T cell numbers or IFN-gamma secretion. B cell numbers were lower in group 1, especially those with low prolactin levels. Independent of this finding, nine of 21 patients in this group had low antibody response to polysaccharide antigen. This was most striking in those with low insulin-like growth factor 1 levels and appeared to be independent of the use of anti-convulsants or corticosteroid replacement. Significant humoral immune deficiency is seen in panhypopituitarism and may contribute to morbidity." @default.
- W2016361601 created "2016-06-24" @default.
- W2016361601 creator A5003192138 @default.
- W2016361601 creator A5006737889 @default.
- W2016361601 creator A5009497247 @default.
- W2016361601 creator A5031139197 @default.
- W2016361601 creator A5048763179 @default.
- W2016361601 creator A5053121427 @default.
- W2016361601 date "2009-02-19" @default.
- W2016361601 modified "2023-09-27" @default.
- W2016361601 title "Failure of antibody response to polysaccharide antigen in treated panhypopituitary adults" @default.
- W2016361601 cites W1971534104 @default.
- W2016361601 cites W1979307276 @default.
- W2016361601 cites W1988940069 @default.
- W2016361601 cites W1996935855 @default.
- W2016361601 cites W1997534554 @default.
- W2016361601 cites W1998092526 @default.
- W2016361601 cites W1999045782 @default.
- W2016361601 cites W2012277787 @default.
- W2016361601 cites W2018616902 @default.
- W2016361601 cites W2018707227 @default.
- W2016361601 cites W2019649345 @default.
- W2016361601 cites W2021674085 @default.
- W2016361601 cites W2021778211 @default.
- W2016361601 cites W2024290133 @default.
- W2016361601 cites W2025704460 @default.
- W2016361601 cites W2025821286 @default.
- W2016361601 cites W2027567560 @default.
- W2016361601 cites W2048289975 @default.
- W2016361601 cites W2064394648 @default.
- W2016361601 cites W2066531498 @default.
- W2016361601 cites W2066609350 @default.
- W2016361601 cites W2067949717 @default.
- W2016361601 cites W2086300138 @default.
- W2016361601 cites W2102990989 @default.
- W2016361601 cites W2116795137 @default.
- W2016361601 cites W2120108803 @default.
- W2016361601 cites W2121471670 @default.
- W2016361601 cites W2125235661 @default.
- W2016361601 cites W2131263920 @default.
- W2016361601 cites W2135531862 @default.
- W2016361601 cites W2137502920 @default.
- W2016361601 cites W2141494612 @default.
- W2016361601 cites W2147740833 @default.
- W2016361601 cites W2163694362 @default.
- W2016361601 cites W2168265093 @default.
- W2016361601 cites W2171368332 @default.
- W2016361601 cites W2329522359 @default.
- W2016361601 doi "https://doi.org/10.1111/j.1365-2249.2009.03881.x" @default.
- W2016361601 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2759475" @default.
- W2016361601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19236430" @default.
- W2016361601 hasPublicationYear "2009" @default.
- W2016361601 type Work @default.
- W2016361601 sameAs 2016361601 @default.
- W2016361601 citedByCount "8" @default.
- W2016361601 countsByYear W20163616012012 @default.
- W2016361601 countsByYear W20163616012013 @default.
- W2016361601 countsByYear W20163616012016 @default.
- W2016361601 countsByYear W20163616012018 @default.
- W2016361601 countsByYear W20163616012023 @default.
- W2016361601 crossrefType "journal-article" @default.
- W2016361601 hasAuthorship W2016361601A5003192138 @default.
- W2016361601 hasAuthorship W2016361601A5006737889 @default.
- W2016361601 hasAuthorship W2016361601A5009497247 @default.
- W2016361601 hasAuthorship W2016361601A5031139197 @default.
- W2016361601 hasAuthorship W2016361601A5048763179 @default.
- W2016361601 hasAuthorship W2016361601A5053121427 @default.
- W2016361601 hasBestOaLocation W20163616011 @default.
- W2016361601 hasConcept C126322002 @default.
- W2016361601 hasConcept C134018914 @default.
- W2016361601 hasConcept C147483822 @default.
- W2016361601 hasConcept C159654299 @default.
- W2016361601 hasConcept C203014093 @default.
- W2016361601 hasConcept C2776090121 @default.
- W2016361601 hasConcept C2779029589 @default.
- W2016361601 hasConcept C71315377 @default.
- W2016361601 hasConcept C71924100 @default.
- W2016361601 hasConcept C86803240 @default.
- W2016361601 hasConcept C8891405 @default.
- W2016361601 hasConceptScore W2016361601C126322002 @default.
- W2016361601 hasConceptScore W2016361601C134018914 @default.
- W2016361601 hasConceptScore W2016361601C147483822 @default.
- W2016361601 hasConceptScore W2016361601C159654299 @default.
- W2016361601 hasConceptScore W2016361601C203014093 @default.
- W2016361601 hasConceptScore W2016361601C2776090121 @default.
- W2016361601 hasConceptScore W2016361601C2779029589 @default.
- W2016361601 hasConceptScore W2016361601C71315377 @default.
- W2016361601 hasConceptScore W2016361601C71924100 @default.
- W2016361601 hasConceptScore W2016361601C86803240 @default.
- W2016361601 hasConceptScore W2016361601C8891405 @default.
- W2016361601 hasIssue "2" @default.
- W2016361601 hasLocation W20163616011 @default.
- W2016361601 hasLocation W20163616012 @default.
- W2016361601 hasLocation W20163616013 @default.
- W2016361601 hasOpenAccess W2016361601 @default.
- W2016361601 hasPrimaryLocation W20163616011 @default.
- W2016361601 hasRelatedWork W1875915725 @default.
- W2016361601 hasRelatedWork W1980914640 @default.