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- W2016362244 abstract "Traumatic injury is a common cause of coagulopathy, primarily due to blood loss and hemodilution secondary to fluid resuscitation. Traumatic injury-associated coagulopathy often follows a course of transition from hyper- to hypocoagulable state exemplified in disseminated intravascular coagulation. The incidence of coagulopathy is significantly higher in patients with traumatic brain injury (TBI), especially those with penetrating trauma compared to injury to the trunk and limbs. This occurs despite the fact that patients with isolated TBI bleed less and receive restricted volume load of fluids. TBI-associated coagulopathy is extensively documented to associate with poor clinical outcomes, but its pathophysiology remains poorly understood. Studies in the past have shown that brain tissue is highly enriched in key procoagulant molecules. This review focuses on the biochemical and cellular characteristics of these molecules and pathways that could make brain uniquely procoagulant and prone to coagulopathy. Understanding this unique procoagulant environment will help to identify new therapeutic targets that could reverse a state of coagulopathy with minimal impacts on hemostasis, a critical requirement for neurosurgical treatments of TBI." @default.
- W2016362244 created "2016-06-24" @default.
- W2016362244 creator A5006630986 @default.
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- W2016362244 creator A5065681513 @default.
- W2016362244 creator A5066453211 @default.
- W2016362244 date "2012-11-20" @default.
- W2016362244 modified "2023-10-03" @default.
- W2016362244 title "Traumatic Brain Injury-Associated Coagulopathy" @default.
- W2016362244 cites W119409406 @default.
- W2016362244 cites W1514947270 @default.
- W2016362244 cites W1522172136 @default.
- W2016362244 cites W1526670106 @default.
- W2016362244 cites W1531706779 @default.
- W2016362244 cites W1570643773 @default.
- W2016362244 cites W1576253698 @default.
- W2016362244 cites W1651376769 @default.
- W2016362244 cites W1692027704 @default.
- W2016362244 cites W1709272109 @default.
- W2016362244 cites W1710033904 @default.
- W2016362244 cites W174048642 @default.
- W2016362244 cites W1850586 @default.
- W2016362244 cites W192119963 @default.
- W2016362244 cites W1965133807 @default.
- W2016362244 cites W1966875441 @default.
- W2016362244 cites W1968188734 @default.
- W2016362244 cites W1968625808 @default.
- W2016362244 cites W1969163496 @default.
- W2016362244 cites W1969719203 @default.
- W2016362244 cites W1970700288 @default.
- W2016362244 cites W1975824095 @default.
- W2016362244 cites W1979674916 @default.
- W2016362244 cites W1979790960 @default.
- W2016362244 cites W1981078609 @default.
- W2016362244 cites W1982684770 @default.
- W2016362244 cites W1983121077 @default.
- W2016362244 cites W1984328775 @default.
- W2016362244 cites W1985924062 @default.
- W2016362244 cites W1988015026 @default.
- W2016362244 cites W1988706691 @default.
- W2016362244 cites W1990157378 @default.
- W2016362244 cites W1990380785 @default.
- W2016362244 cites W1990483611 @default.
- W2016362244 cites W1991438089 @default.
- W2016362244 cites W1994814932 @default.
- W2016362244 cites W1996838219 @default.
- W2016362244 cites W1997738018 @default.
- W2016362244 cites W1997902272 @default.
- W2016362244 cites W1999735248 @default.
- W2016362244 cites W2001866634 @default.
- W2016362244 cites W2003096217 @default.
- W2016362244 cites W2005353831 @default.
- W2016362244 cites W2005669851 @default.
- W2016362244 cites W2007886222 @default.
- W2016362244 cites W2010130396 @default.
- W2016362244 cites W2011977611 @default.
- W2016362244 cites W2012299366 @default.
- W2016362244 cites W2015736975 @default.
- W2016362244 cites W2017192929 @default.
- W2016362244 cites W2019199464 @default.
- W2016362244 cites W2020196495 @default.
- W2016362244 cites W2022177860 @default.
- W2016362244 cites W2025071036 @default.
- W2016362244 cites W2025188325 @default.
- W2016362244 cites W2026152131 @default.
- W2016362244 cites W2026907051 @default.
- W2016362244 cites W2027028949 @default.
- W2016362244 cites W2027353137 @default.
- W2016362244 cites W2028365275 @default.
- W2016362244 cites W2028366669 @default.
- W2016362244 cites W2029271798 @default.
- W2016362244 cites W2030241652 @default.
- W2016362244 cites W2030669625 @default.
- W2016362244 cites W2033156873 @default.
- W2016362244 cites W2034656907 @default.
- W2016362244 cites W2037377791 @default.
- W2016362244 cites W2038317817 @default.
- W2016362244 cites W2040831881 @default.
- W2016362244 cites W2041069934 @default.
- W2016362244 cites W2041173746 @default.
- W2016362244 cites W2041890590 @default.
- W2016362244 cites W2044505929 @default.
- W2016362244 cites W2045189723 @default.
- W2016362244 cites W2046428162 @default.
- W2016362244 cites W2048928322 @default.
- W2016362244 cites W2049886060 @default.
- W2016362244 cites W2050170713 @default.
- W2016362244 cites W2050683932 @default.
- W2016362244 cites W2051148897 @default.
- W2016362244 cites W2052880620 @default.
- W2016362244 cites W2054657407 @default.
- W2016362244 cites W2056476122 @default.
- W2016362244 cites W2056887853 @default.
- W2016362244 cites W2058370142 @default.
- W2016362244 cites W2065121216 @default.
- W2016362244 cites W2067902059 @default.