FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016365877> ?p ?o ?g. }

• W2016365877 endingPage "519" @default.
• W2016365877 startingPage "512" @default.
• W2016365877 abstract "Prolonged overeating and the resultant weight gain are clearly linked with the development of insulin resistance and other cardiometabolic abnormalities, but adaptations that occur after relatively short periods of overeating are not completely understood. The purpose of this study was to characterize metabolic adaptations that may accompany the development of insulin resistance after 2 weeks of overeating. Healthy, nonobese subjects (n = 9) were admitted to the hospital for 2 weeks, during which time they ate ∼4000 kcals·day −1 (70 kcal·kg −1 fat free mass·day −1 ). Insulin sensitivity was estimated during a meal tolerance test, and a muscle biopsy was obtained to assess muscle lipid accumulation and protein markers associated with insulin resistance, inflammation, and the regulation of lipid metabolism. Whole-body insulin sensitivity declined markedly after 2 weeks of overeating (Matsuda composite index: 8.3 ± 1.3 vs. 4.6 ± 0.7, p < 0.05). However, muscle markers of insulin resistance and inflammation (i.e., phosphorylation of IRS-1-Ser 312 , Akt-Ser 473 , and c-Jun N-terminal kinase) were not altered by overeating. Intramyocellular lipids tended to increase after 2 weeks of overeating (triacylglyceride: 7.6 ± 1.6 vs. 10.0 ± 1.8 nmol·mg −1 wet weight; diacylglyceride: 104 ± 10 vs. 142 ± 23 pmol·mg −1 wet weight) but these changes did not reach statistical significance. Overeating induced a 2-fold increase in 24-h insulin response (area under the curve (AUC); p < 0.05), with a resultant ∼35% reduction in 24-h plasma fatty acid AUC (p < 0.05). This chronic reduction in circulating fatty acids may help explain the lack of a robust increase in muscle lipid accumulation. In summary, our findings suggest alterations in skeletal muscle metabolism may not contribute meaningfully to the marked whole-body insulin resistance observed after 2 weeks of overeating." @default.
• W2016365877 created "2016-06-24" @default.
• W2016365877 creator A5011052758 @default.
• W2016365877 creator A5015784404 @default.
• W2016365877 creator A5036287281 @default.
• W2016365877 creator A5070156813 @default.
• W2016365877 creator A5071444803 @default.
• W2016365877 date "2013-05-01" @default.
• W2016365877 modified "2023-09-26" @default.
• W2016365877 title "Rapid development of systemic insulin resistance with overeating is not accompanied by robust changes in skeletal muscle glucose and lipid metabolism" @default.
• W2016365877 cites W137392825 @default.
• W2016365877 cites W1537149240 @default.
• W2016365877 cites W162198717 @default.
• W2016365877 cites W1844998737 @default.
• W2016365877 cites W1964946280 @default.
• W2016365877 cites W1968413141 @default.
• W2016365877 cites W1986798717 @default.
• W2016365877 cites W1996983786 @default.
• W2016365877 cites W1997192581 @default.
• W2016365877 cites W1997882484 @default.
• W2016365877 cites W2019836230 @default.
• W2016365877 cites W2020799782 @default.
• W2016365877 cites W2027668700 @default.
• W2016365877 cites W2030065542 @default.
• W2016365877 cites W2034086375 @default.
• W2016365877 cites W2038018821 @default.
• W2016365877 cites W2041811148 @default.
• W2016365877 cites W2046220668 @default.
• W2016365877 cites W2049078566 @default.
• W2016365877 cites W2055872797 @default.
• W2016365877 cites W2058176125 @default.
• W2016365877 cites W2068769790 @default.
• W2016365877 cites W2071867050 @default.
• W2016365877 cites W2076232786 @default.
• W2016365877 cites W2081324449 @default.
• W2016365877 cites W2081478664 @default.
• W2016365877 cites W2086558246 @default.
• W2016365877 cites W2099024651 @default.
• W2016365877 cites W2100003568 @default.
• W2016365877 cites W2102683312 @default.
• W2016365877 cites W2110943180 @default.
• W2016365877 cites W2111817213 @default.
• W2016365877 cites W2113505181 @default.
• W2016365877 cites W2113511371 @default.
• W2016365877 cites W2114420424 @default.
• W2016365877 cites W2126847200 @default.
• W2016365877 cites W2130200187 @default.
• W2016365877 cites W2130850001 @default.
• W2016365877 cites W2133795831 @default.
• W2016365877 cites W2136060691 @default.
• W2016365877 cites W2136226749 @default.
• W2016365877 cites W2147075074 @default.
• W2016365877 cites W2156690149 @default.
• W2016365877 cites W2160234571 @default.
• W2016365877 cites W2164418602 @default.
• W2016365877 cites W2165821704 @default.
• W2016365877 cites W2168519267 @default.
• W2016365877 cites W2168584545 @default.
• W2016365877 cites W2169130568 @default.
• W2016365877 cites W2300552860 @default.
• W2016365877 cites W4236159860 @default.
• W2016365877 cites W4240803552 @default.
• W2016365877 cites W4256606448 @default.
• W2016365877 doi "https://doi.org/10.1139/apnm-2012-0266" @default.
• W2016365877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3891585" @default.
• W2016365877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23668758" @default.
• W2016365877 hasPublicationYear "2013" @default.
• W2016365877 type Work @default.
• W2016365877 sameAs 2016365877 @default.
• W2016365877 citedByCount "16" @default.
• W2016365877 countsByYear W20163658772014 @default.
• W2016365877 countsByYear W20163658772015 @default.
• W2016365877 countsByYear W20163658772016 @default.
• W2016365877 countsByYear W20163658772017 @default.
• W2016365877 countsByYear W20163658772018 @default.
• W2016365877 countsByYear W20163658772019 @default.
• W2016365877 countsByYear W20163658772020 @default.
• W2016365877 countsByYear W20163658772021 @default.
• W2016365877 countsByYear W20163658772022 @default.
• W2016365877 countsByYear W20163658772023 @default.
• W2016365877 crossrefType "journal-article" @default.
• W2016365877 hasAuthorship W2016365877A5011052758 @default.
• W2016365877 hasAuthorship W2016365877A5015784404 @default.
• W2016365877 hasAuthorship W2016365877A5036287281 @default.
• W2016365877 hasAuthorship W2016365877A5070156813 @default.
• W2016365877 hasAuthorship W2016365877A5071444803 @default.
• W2016365877 hasBestOaLocation W20163658772 @default.
• W2016365877 hasConcept C126322002 @default.
• W2016365877 hasConcept C134018914 @default.
• W2016365877 hasConcept C185592680 @default.
• W2016365877 hasConcept C2777391703 @default.
• W2016365877 hasConcept C2778792376 @default.
• W2016365877 hasConcept C2779306644 @default.
• W2016365877 hasConcept C2779772378 @default.
• W2016365877 hasConcept C2779959927 @default.
• W2016365877 hasConcept C4733338 @default.
• W2016365877 hasConcept C511355011 @default.
• W2016365877 hasConcept C71924100 @default.

• next