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• W2016368711 abstract "It has long been speculated that cellular microdomains are important for many cellular processes, especially those involving Ca2+ signalling. Measurements of cytosolic Ca2+ report maximum concentrations of less than few micromolar, yet several cytosolic enzymes require concentrations of more than 20 microM Ca2+ to be activated. In this paper, we have resolved this apparent paradox by showing that the surface topology of cells represents an important and hitherto unrecognized feature for generating microdomains of high Ca2+ in cells. We show that whereas the standard modeling assumption of a smooth cell surface predicts only moderate localized effects, the more realistic wrinkled surface topology predicts that Ca2+ concentrations up to 80 microM can persist within the folds of membranes for significant times. This intra-wrinkle location may account for 5% of the total cell volume. Using different geometries of wrinkles, our simulations show that high Ca2+ microdomains will be generated most effectively by long narrow membrane wrinkles of similar dimensions to those found experimentally. This is a new concept which has not previously been considered, but which has ramifications as the intra-wrinkle location is also a strategic location at which Ca2+ acts as a regulator of the cortical cytoskeleton and plasma membrane expansion." @default.
• W2016368711 created "2016-06-24" @default.
• W2016368711 creator A5043479280 @default.
• W2016368711 creator A5068328382 @default.
• W2016368711 creator A5077891831 @default.
• W2016368711 date "2010-04-01" @default.
• W2016368711 modified "2023-10-04" @default.
• W2016368711 title "Cell surface topology creates high Ca2+ signalling microdomains" @default.
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• W2016368711 doi "https://doi.org/10.1016/j.ceca.2010.01.005" @default.
• W2016368711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2877796" @default.
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