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- W2016369481 abstract "Acetylcholine (ACh) induced concentration-dependent relaxations of rabbit aortic strips precontracted with noradrenaline. The relaxations were abolished if the endothelium of the strips was disrupted. Three different antioxidants (butylated hydroxytoluene, dithiothreitol and alpha-tocopherol) reversed the endothelium-dependent vasodilation in a concentration-dependent manner. However, the antioxidant ascorbic acid did not alter the vasodilatation. The hydroxylated eicosatetraenoic acids 5-HETE, 12-HETE, 15-HETE and 5,12-diHETE had no effect on aortic strips under basal or induced tension. These results suggest, that (non-cyclo-oxygenase) oxidation processes, insensitive to the action of ascorbic acid, represent a crucial step in the endothelium-dependent dilatation of rabbit aorta by ACh. The hydroxylated fatty acids tested are unlikely to mediate this relaxation." @default.
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- W2016369481 title "The endothelium-dependent relaxation of rabbit aorta: effects of antioxidants and hydroxylated eicosatetraenoic acids" @default.
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- W2016369481 doi "https://doi.org/10.1111/j.1476-5381.1984.tb16472.x" @default.
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