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• W2016369535 abstract "To exploit the biological and pharmacological properties of immunoglobulin constant domain Fc fragment and increase the killing efficacy of T cells, a single chain variable fragment specific to CD3 was fused with Fcab (Fc antigen binding), a mutant Fc fragment with specificity against Human epidermal growth factor receptor 2 (HER2) developed by F-star. The bispecific fusion named as FcabCD3 was expressed by transient transfection in HEK-293T cells and purified by affinity chromatography. Specific cytolytic activity of retargeted T cells to kill HER2 positive SKBR3 cell line was evaluated in vitro. FcabCD3 was able to retarget T cells to kill both Herceptin insensitive Colo205-luc cell line and HER2 low expression MDA-MB-231-luc cell line. Furthermore, FcabCD3 was effective in eliminating the Colo205 tumor established on BALB/c nu/nu mice." @default.
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• W2016369535 date "2013-09-23" @default.
• W2016369535 modified "2023-10-18" @default.
• W2016369535 title "Retargeting T Cells for HER2-Positive Tumor Killing by a Bispecific Fv-Fc Antibody" @default.
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• W2016369535 doi "https://doi.org/10.1371/journal.pone.0075589" @default.
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