FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016371338> ?p ?o ?g. }

• W2016371338 endingPage "10672" @default.
• W2016371338 startingPage "10668" @default.
• W2016371338 abstract "The circadian clock in mammalian organisms is generated by a transcription–translation feedback loop that controls many biochemical pathways at the cellular level and physiology and behavior at the organismal level. Cryptochrome (Cry) is a key protein in the negative arm of the transcription–translation feedback loop. It has been found that Cry mutation in cells with p53-null genotype increased their sensitivity to apoptosis by genotoxic agents. Here we show that this increased sensitivity is due to up-regulation of the p53 gene family member p73 in response to DNA damage. As a consequence, when tumors arising from oncogenic Ras-transformed p53 −/− and p53 −/− Cry1 −/− Cry2 −/− cells are treated with the anticancer drug oxaliplatin, p53 −/− tumors continue to grow whereas p53 −/− Cry1 −/− Cry2 −/− tumors exhibit extensive apoptosis and stop growing. This finding provides a mechanistic foundation for overcoming the resistance of p53-deficient tumor cells to apoptosis induced by DNA-damaging agents and suggests that disruption of cryptochrome function may increase the sensitivity of tumors with p53 mutation to chemotherapy." @default.
• W2016371338 created "2016-06-24" @default.
• W2016371338 creator A5016678671 @default.
• W2016371338 creator A5077212478 @default.
• W2016371338 date "2011-05-31" @default.
• W2016371338 modified "2023-09-25" @default.
• W2016371338 title "Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis" @default.
• W2016371338 cites W1520563041 @default.
• W2016371338 cites W1607777232 @default.
• W2016371338 cites W161836838 @default.
• W2016371338 cites W1675096266 @default.
• W2016371338 cites W1966292443 @default.
• W2016371338 cites W1976540475 @default.
• W2016371338 cites W1979319210 @default.
• W2016371338 cites W1986406178 @default.
• W2016371338 cites W1991172285 @default.
• W2016371338 cites W2003302378 @default.
• W2016371338 cites W2005013681 @default.
• W2016371338 cites W2008986803 @default.
• W2016371338 cites W2012024423 @default.
• W2016371338 cites W2013244539 @default.
• W2016371338 cites W2021607553 @default.
• W2016371338 cites W2034918846 @default.
• W2016371338 cites W2078242867 @default.
• W2016371338 cites W2080448673 @default.
• W2016371338 cites W2081894694 @default.
• W2016371338 cites W2086473844 @default.
• W2016371338 cites W2101600063 @default.
• W2016371338 cites W2112881364 @default.
• W2016371338 cites W2115989915 @default.
• W2016371338 cites W2126787895 @default.
• W2016371338 cites W2130177169 @default.
• W2016371338 cites W2133050919 @default.
• W2016371338 cites W2164938315 @default.
• W2016371338 doi "https://doi.org/10.1073/pnas.1106284108" @default.
• W2016371338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3127903" @default.
• W2016371338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21628572" @default.
• W2016371338 hasPublicationYear "2011" @default.
• W2016371338 type Work @default.
• W2016371338 sameAs 2016371338 @default.
• W2016371338 citedByCount "57" @default.
• W2016371338 countsByYear W20163713382012 @default.
• W2016371338 countsByYear W20163713382013 @default.
• W2016371338 countsByYear W20163713382014 @default.
• W2016371338 countsByYear W20163713382015 @default.
• W2016371338 countsByYear W20163713382016 @default.
• W2016371338 countsByYear W20163713382017 @default.
• W2016371338 countsByYear W20163713382018 @default.
• W2016371338 countsByYear W20163713382019 @default.
• W2016371338 countsByYear W20163713382020 @default.
• W2016371338 countsByYear W20163713382021 @default.
• W2016371338 countsByYear W20163713382022 @default.
• W2016371338 countsByYear W20163713382023 @default.
• W2016371338 crossrefType "journal-article" @default.
• W2016371338 hasAuthorship W2016371338A5016678671 @default.
• W2016371338 hasAuthorship W2016371338A5077212478 @default.
• W2016371338 hasBestOaLocation W20163713381 @default.
• W2016371338 hasConcept C104317684 @default.
• W2016371338 hasConcept C134935766 @default.
• W2016371338 hasConcept C138885662 @default.
• W2016371338 hasConcept C143425029 @default.
• W2016371338 hasConcept C144543706 @default.
• W2016371338 hasConcept C179926584 @default.
• W2016371338 hasConcept C190283241 @default.
• W2016371338 hasConcept C38606739 @default.
• W2016371338 hasConcept C41895202 @default.
• W2016371338 hasConcept C501734568 @default.
• W2016371338 hasConcept C502942594 @default.
• W2016371338 hasConcept C54355233 @default.
• W2016371338 hasConcept C552990157 @default.
• W2016371338 hasConcept C86339819 @default.
• W2016371338 hasConcept C86803240 @default.
• W2016371338 hasConcept C95444343 @default.
• W2016371338 hasConceptScore W2016371338C104317684 @default.
• W2016371338 hasConceptScore W2016371338C134935766 @default.
• W2016371338 hasConceptScore W2016371338C138885662 @default.
• W2016371338 hasConceptScore W2016371338C143425029 @default.
• W2016371338 hasConceptScore W2016371338C144543706 @default.
• W2016371338 hasConceptScore W2016371338C179926584 @default.
• W2016371338 hasConceptScore W2016371338C190283241 @default.
• W2016371338 hasConceptScore W2016371338C38606739 @default.
• W2016371338 hasConceptScore W2016371338C41895202 @default.
• W2016371338 hasConceptScore W2016371338C501734568 @default.
• W2016371338 hasConceptScore W2016371338C502942594 @default.
• W2016371338 hasConceptScore W2016371338C54355233 @default.
• W2016371338 hasConceptScore W2016371338C552990157 @default.
• W2016371338 hasConceptScore W2016371338C86339819 @default.
• W2016371338 hasConceptScore W2016371338C86803240 @default.
• W2016371338 hasConceptScore W2016371338C95444343 @default.
• W2016371338 hasIssue "26" @default.
• W2016371338 hasLocation W20163713381 @default.
• W2016371338 hasLocation W20163713382 @default.
• W2016371338 hasLocation W20163713383 @default.
• W2016371338 hasLocation W20163713384 @default.
• W2016371338 hasLocation W20163713385 @default.
• W2016371338 hasLocation W20163713386 @default.
• W2016371338 hasOpenAccess W2016371338 @default.
• W2016371338 hasPrimaryLocation W20163713381 @default.

• next