FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016373146> ?p ?o ?g. }

• W2016373146 endingPage "927" @default.
• W2016373146 startingPage "918" @default.
• W2016373146 abstract "Previous research has suggested that repletion of cellular glutathione peroxidase (GPX1) activity by a single injection of Se was dissociated from the Se protection against the pro-oxidant-induced liver necrosis in Se-deficient rodents. Using the GPX1 knockout (GPX1-/-) mice, TUNEL assay, and apoptosis gene expression microarray, we have demonstrated strikingly different impacts of GPX1 knockout on hepatotoxicity and the related signaling induced by an intraperitoneal injection of 12.5 mg paraquat/kg body weight (b.wt.). In both Se-deficient GPX1-/- and wild-type (WT) mice, the paraquat did not induce typical liver necrosis, rather aponecrosis or necrapoptosis, a syncretic process of cell death sharing characteristics of both apoptosis and necrosis. The severity of liver aponecrosis and the associated mortality were reduced to a much greater extent by an injection of Se (ip, 50 microg/kg b.wt. as Na2SeO3) prior to paraquat stress in the WT mice, compared with the GPX1-/- mice. The induced liver aponecrosis seemed to be more apoptotic in the GPX1-/- mice but more necrotic in the WT mice. The paraquat-mediated gene or protein expression of proapoptotic Bax, Bcl-w, and Bcl-X(S), cell survival/death factors GADD45, MDM2, c-Myc, and caspase-3 was upregulated, but that of antiapoptotic Bcl-2 was downregulated in the GPX1-/- mice vs. the WT mice. Overall, these differences between the two groups of mice were related to a low level of liver GPX1 activity in the WT mice that represented < 4% of the normal physiological level. Therefore, the low level of GPX1 activity in the Se-deficient mice can exert a potent role in defending against liver aponecrosis induced by moderate oxidative stress." @default.
• W2016373146 created "2016-06-24" @default.
• W2016373146 creator A5017115807 @default.
• W2016373146 creator A5064131093 @default.
• W2016373146 creator A5074486459 @default.
• W2016373146 date "2003-04-01" @default.
• W2016373146 modified "2023-10-12" @default.
• W2016373146 title "Impacts of glutathione peroxidase-1 knockout on the protection by injected selenium against the pro-oxidant-induced liver aponecrosis and signaling in selenium-deficient mice" @default.
• W2016373146 cites W1610329392 @default.
• W2016373146 cites W1657827244 @default.
• W2016373146 cites W172276776 @default.
• W2016373146 cites W1888475249 @default.
• W2016373146 cites W1962843014 @default.
• W2016373146 cites W1963564737 @default.
• W2016373146 cites W1966597352 @default.
• W2016373146 cites W1967794318 @default.
• W2016373146 cites W1967880683 @default.
• W2016373146 cites W1970010697 @default.
• W2016373146 cites W1974017120 @default.
• W2016373146 cites W1991494214 @default.
• W2016373146 cites W1992412942 @default.
• W2016373146 cites W1995505431 @default.
• W2016373146 cites W2000568975 @default.
• W2016373146 cites W2002304768 @default.
• W2016373146 cites W2002860741 @default.
• W2016373146 cites W2006313098 @default.
• W2016373146 cites W2007861801 @default.
• W2016373146 cites W2012936769 @default.
• W2016373146 cites W2016510892 @default.
• W2016373146 cites W2022814481 @default.
• W2016373146 cites W2039610545 @default.
• W2016373146 cites W2045086385 @default.
• W2016373146 cites W2052452850 @default.
• W2016373146 cites W2054877890 @default.
• W2016373146 cites W2056695281 @default.
• W2016373146 cites W2060194897 @default.
• W2016373146 cites W2063991756 @default.
• W2016373146 cites W2066299890 @default.
• W2016373146 cites W2066639890 @default.
• W2016373146 cites W2077490461 @default.
• W2016373146 cites W2083906562 @default.
• W2016373146 cites W2084001753 @default.
• W2016373146 cites W2092548393 @default.
• W2016373146 cites W2101575450 @default.
• W2016373146 cites W2113999599 @default.
• W2016373146 cites W2115971178 @default.
• W2016373146 cites W2117089540 @default.
• W2016373146 cites W2123572537 @default.
• W2016373146 cites W2129314792 @default.
• W2016373146 cites W2132411546 @default.
• W2016373146 cites W2134140021 @default.
• W2016373146 cites W2145645476 @default.
• W2016373146 cites W2147357406 @default.
• W2016373146 cites W2147418323 @default.
• W2016373146 cites W2155782446 @default.
• W2016373146 cites W2162532471 @default.
• W2016373146 cites W2167519860 @default.
• W2016373146 cites W2301670026 @default.
• W2016373146 cites W2319368919 @default.
• W2016373146 cites W2323678549 @default.
• W2016373146 doi "https://doi.org/10.1016/s0891-5849(03)00021-2" @default.
• W2016373146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12654481" @default.
• W2016373146 hasPublicationYear "2003" @default.
• W2016373146 type Work @default.
• W2016373146 sameAs 2016373146 @default.
• W2016373146 citedByCount "47" @default.
• W2016373146 countsByYear W20163731462012 @default.
• W2016373146 countsByYear W20163731462013 @default.
• W2016373146 countsByYear W20163731462014 @default.
• W2016373146 countsByYear W20163731462015 @default.
• W2016373146 countsByYear W20163731462016 @default.
• W2016373146 countsByYear W20163731462017 @default.
• W2016373146 countsByYear W20163731462018 @default.
• W2016373146 countsByYear W20163731462021 @default.
• W2016373146 countsByYear W20163731462023 @default.
• W2016373146 crossrefType "journal-article" @default.
• W2016373146 hasAuthorship W2016373146A5017115807 @default.
• W2016373146 hasAuthorship W2016373146A5064131093 @default.
• W2016373146 hasAuthorship W2016373146A5074486459 @default.
• W2016373146 hasConcept C104317684 @default.
• W2016373146 hasConcept C126322002 @default.
• W2016373146 hasConcept C134018914 @default.
• W2016373146 hasConcept C153911025 @default.
• W2016373146 hasConcept C158086472 @default.
• W2016373146 hasConcept C181199279 @default.
• W2016373146 hasConcept C182704531 @default.
• W2016373146 hasConcept C185592680 @default.
• W2016373146 hasConcept C190283241 @default.
• W2016373146 hasConcept C196795494 @default.
• W2016373146 hasConcept C203663253 @default.
• W2016373146 hasConcept C2775838275 @default.
• W2016373146 hasConcept C2776151105 @default.
• W2016373146 hasConcept C2776527163 @default.
• W2016373146 hasConcept C2776637226 @default.
• W2016373146 hasConcept C2778760513 @default.
• W2016373146 hasConcept C2780159080 @default.
• W2016373146 hasConcept C31573885 @default.
• W2016373146 hasConcept C503630168 @default.

• next