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• W2016374414 abstract "BackgroundPost‐operative hepatic dysfunction is a major cause of concern when undertaking a liver resection. The generation of reactive oxygen species (ROS) as a result of hepatic ischaemia/reperfusion (I/R) injury can result in hepatocellular injury. Experimental evidence suggests that N‐acetylcysteine may ameliorate ROS‐mediated liver injury.MethodsA cohort of 44 patients who had undergone a liver resection and receiving peri‐operative N‐acetylcysteine (NAC) were compared with a further cohort of 44 patients who did not. Liver function tests were compared on post‐operative days 1, 3 and 5. Peri‐operative outcome data were retrieved from a prospectively maintained database within our unit.ResultsAdministration of NAC was associated with a prolonged prothrombin time on the third post‐operative day (18.4 versus 16.4 s; P = 0.002). The incidence of grades B and C liver failure was lower in the NAC group although this difference did not reach statistical significance (6.9% versus 14%; P = 0.287). The overall complication rate was similar between groups (32% versus 25%; P = ns). There were two peri‐operative deaths in the NAC group and one in the control group (P = NS).ConclusionIn spite of promising experimental evidence, this study was not able to demonstrate any advantage in the routine administration of peri‐operative NAC in patients undergoing a liver resection." @default.
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• W2016374414 date "2013-06-01" @default.
• W2016374414 modified "2023-09-26" @default.
• W2016374414 title "N‐acetylcysteine administration does not improve patient outcome after liver resection" @default.
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• W2016374414 doi "https://doi.org/10.1111/hpb.12005" @default.
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