FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016378268> ?p ?o ?g. }

• W2016378268 endingPage "487" @default.
• W2016378268 startingPage "482" @default.
• W2016378268 abstract "We have demonstrated previously that pemphigus vulgaris (PV)-IgG induces activation of phospholipase C (PLC), production of inositol 1,4,5-trisphosphate, and a rapid transient increase in [Ca2+]i in cultured human keratinocytes, leading to secretion of plasminogen activator and cell-cell detachment in cell culture. In the current study, to examine the involvement of protein kinase C (PKC) in the mechanism of blister formation in PV, we studied the PV-IgG-induced translocation of PKC isozymes from the cytosol to the particulate/cytoskeleton (p/c) fractions and the activation of PKC in human keratinocytes. Cells cultured in Eagle's minimum essential medium were incubated with PV-IgGs for 30 s, 1 min, 5 min, or 30 min. PV-IgG binding to the cell surface antigen (desmoglein III) induced translocation of PKC-alpha from the cytosol to the p/c fractions within 30 s, with a peak at 1 min that lasted at least 30 min. PKC-delta also was translocated within 1 min and reached a peak at 5 min but was reduced to basal levels at 30 min. Alternatively, PKC-eta translocation to the p/c fraction was induced slowly, taking more than 5 min, and was reduced to approximately half-maximum at 30 min, whereas PKC-zeta translocation reached a maximum at 30 s, rapidly returning to baseline by 5 min after PV-IgG stimulation. The total PKC activity in the p/c fraction also was increased after PV-IgG exposure, peaked at 1 min, and was sustained for at least 30 min. These findings suggest that a unique activation profile of PKC isomers may be involved in mediating the intracellular signaling events induced by PV-IgG binding to desmoglein III in cultured human keratinocytes." @default.
• W2016378268 created "2016-06-24" @default.
• W2016378268 creator A5003998870 @default.
• W2016378268 creator A5028839003 @default.
• W2016378268 creator A5068871097 @default.
• W2016378268 date "1997-04-01" @default.
• W2016378268 modified "2023-10-14" @default.
• W2016378268 title "Pemphigus IgG Activates and Translocates Protein Kinase C from the Cytosol to the Particulate/Cytoskeleton Fractions in Human Keratinocytes" @default.
• W2016378268 cites W1492157617 @default.
• W2016378268 cites W1504962298 @default.
• W2016378268 cites W1537302992 @default.
• W2016378268 cites W1564302359 @default.
• W2016378268 cites W1589100504 @default.
• W2016378268 cites W1598566391 @default.
• W2016378268 cites W1598911721 @default.
• W2016378268 cites W1678773327 @default.
• W2016378268 cites W1895058071 @default.
• W2016378268 cites W1924274239 @default.
• W2016378268 cites W1993264150 @default.
• W2016378268 cites W1993282564 @default.
• W2016378268 cites W2019799755 @default.
• W2016378268 cites W2032712713 @default.
• W2016378268 cites W2038833016 @default.
• W2016378268 cites W2049319080 @default.
• W2016378268 cites W2053532688 @default.
• W2016378268 cites W2054380158 @default.
• W2016378268 cites W2057784301 @default.
• W2016378268 cites W2058143679 @default.
• W2016378268 cites W2062545414 @default.
• W2016378268 cites W2065247462 @default.
• W2016378268 cites W2077547402 @default.
• W2016378268 cites W2086524338 @default.
• W2016378268 cites W2089101401 @default.
• W2016378268 cites W2100837269 @default.
• W2016378268 cites W2121497408 @default.
• W2016378268 cites W2126923765 @default.
• W2016378268 cites W2132644765 @default.
• W2016378268 cites W2144891441 @default.
• W2016378268 cites W2157124714 @default.
• W2016378268 cites W2335080074 @default.
• W2016378268 cites W4253357698 @default.
• W2016378268 doi "https://doi.org/10.1111/1523-1747.ep12289726" @default.
• W2016378268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9077478" @default.
• W2016378268 hasPublicationYear "1997" @default.
• W2016378268 type Work @default.
• W2016378268 sameAs 2016378268 @default.
• W2016378268 citedByCount "108" @default.
• W2016378268 countsByYear W20163782682012 @default.
• W2016378268 countsByYear W20163782682013 @default.
• W2016378268 countsByYear W20163782682014 @default.
• W2016378268 countsByYear W20163782682015 @default.
• W2016378268 countsByYear W20163782682016 @default.
• W2016378268 countsByYear W20163782682017 @default.
• W2016378268 countsByYear W20163782682018 @default.
• W2016378268 countsByYear W20163782682019 @default.
• W2016378268 countsByYear W20163782682020 @default.
• W2016378268 countsByYear W20163782682021 @default.
• W2016378268 countsByYear W20163782682022 @default.
• W2016378268 countsByYear W20163782682023 @default.
• W2016378268 crossrefType "journal-article" @default.
• W2016378268 hasAuthorship W2016378268A5003998870 @default.
• W2016378268 hasAuthorship W2016378268A5028839003 @default.
• W2016378268 hasAuthorship W2016378268A5068871097 @default.
• W2016378268 hasBestOaLocation W20163782681 @default.
• W2016378268 hasConcept C104317684 @default.
• W2016378268 hasConcept C138626823 @default.
• W2016378268 hasConcept C142669718 @default.
• W2016378268 hasConcept C1491633281 @default.
• W2016378268 hasConcept C153911025 @default.
• W2016378268 hasConcept C181199279 @default.
• W2016378268 hasConcept C184235292 @default.
• W2016378268 hasConcept C185592680 @default.
• W2016378268 hasConcept C195794163 @default.
• W2016378268 hasConcept C55493867 @default.
• W2016378268 hasConcept C86803240 @default.
• W2016378268 hasConcept C95444343 @default.
• W2016378268 hasConcept C98539663 @default.
• W2016378268 hasConceptScore W2016378268C104317684 @default.
• W2016378268 hasConceptScore W2016378268C138626823 @default.
• W2016378268 hasConceptScore W2016378268C142669718 @default.
• W2016378268 hasConceptScore W2016378268C1491633281 @default.
• W2016378268 hasConceptScore W2016378268C153911025 @default.
• W2016378268 hasConceptScore W2016378268C181199279 @default.
• W2016378268 hasConceptScore W2016378268C184235292 @default.
• W2016378268 hasConceptScore W2016378268C185592680 @default.
• W2016378268 hasConceptScore W2016378268C195794163 @default.
• W2016378268 hasConceptScore W2016378268C55493867 @default.
• W2016378268 hasConceptScore W2016378268C86803240 @default.
• W2016378268 hasConceptScore W2016378268C95444343 @default.
• W2016378268 hasConceptScore W2016378268C98539663 @default.
• W2016378268 hasIssue "4" @default.
• W2016378268 hasLocation W20163782681 @default.
• W2016378268 hasLocation W20163782682 @default.
• W2016378268 hasOpenAccess W2016378268 @default.
• W2016378268 hasPrimaryLocation W20163782681 @default.
• W2016378268 hasRelatedWork W1515198288 @default.
• W2016378268 hasRelatedWork W1963601506 @default.
• W2016378268 hasRelatedWork W1987352359 @default.

• next