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- W2016379570 abstract "Somatic mutations are common event in multicellular organisms and, therefore, have a significant impact on health. They can lead to either heterozygosity or homozygosity. Since the multistep concept of carcinogenesis presupposes that mutations/deletions of several genes are acquired, the identification and location of the critical genes involved in this sequence is attempted either by the observation of cytogenetic or molecular abnormalities in tumorous tissue or by linkage analysis, or both. The retinoblastoma paradigm of loss of heterozygosity with respect to the loss of the only wild-type allele can be applied to familial neoplasias occurring in all organs as they are summarized in this review. The development of homozygosity in non-malignant tissue has not been extensively investigated. However, its study has contributed to the identification of new genetic phenomena such as parental unidisomy and genomic imprinting." @default.
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- W2016379570 modified "2023-10-17" @default.
- W2016379570 title "Hereditary conditions in which the loss of heterozygosity may be important" @default.
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- W2016379570 doi "https://doi.org/10.1016/0027-5107(92)90021-s" @default.
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