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• W2016380819 endingPage "25" @default.
• W2016380819 startingPage "12" @default.
• W2016380819 abstract "The presence of maternal cells in the organs of the offspring is referred to as maternal microchimerism (MMc). MMc is physiologically acquired during pregnancy and lactation and can persist until adulthood. The detection of MMc in a variety of human diseases has raised interest in the short- and long-term functional consequences for the offspring. Owing to limited availability and access to human tissue, mouse models have become an essential tool in elucidating the functional role of MMc. This review compiles the detection techniques and experimental settings used in murine MMc research. It aims to summarize the potential mechanisms of migration of MMc, pre- and postnatal tissue distribution, phenotype and concatenated function, as well as factors modulating its occurrence. In this context, we propose MMc to be a materno-fetal messenger with the capacity to critically shape the development of the offspring's immunity." @default.
• W2016380819 created "2016-06-24" @default.
• W2016380819 creator A5030053511 @default.
• W2016380819 creator A5055336569 @default.
• W2016380819 creator A5091588670 @default.
• W2016380819 date "2015-04-01" @default.
• W2016380819 modified "2023-09-26" @default.
• W2016380819 title "Maternal microchimerism: lessons learned from murine models" @default.
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