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• W2016381343 abstract "Gene therapy for pulmonary disease, a field still in the experimental stage, has nonetheless progressed considerably in the past decade. There have been significant advances in pre-clinical studies, as well as important developments resulting from multiple early-phase human clinical trials for a variety of respiratory disorders. Although there are several ways of delivering therapeutic genes to the lungs, the primary delivery modality remains flexible bronchoscopy. The flexible bronchoscope, because of its unique access to both large and small airways, serves as an ideal instrument to deliver therapeutic genes to the tracheobronchial tree, even to small airways and alveoli that are beyond the reach of the bronchoscope. In addition, bronchoscopic gene delivery has the capacity to treat pulmonary vascular disorders because delivery of marker and therapeutic genes via the airways has been demonstrated to successfully transduce the pulmonary vascular endothelium. This article describes the various methods and disease targets of bronchoscopically mediated gene therapy, focusing in particular on the results of clinical studies and providing a glimpse into the future of the field." @default.
• W2016381343 created "2016-06-24" @default.
• W2016381343 creator A5022802228 @default.
• W2016381343 creator A5077963785 @default.
• W2016381343 date "2004-08-01" @default.
• W2016381343 modified "2023-10-05" @default.
• W2016381343 title "Endobronchial Gene Therapy" @default.
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• W2016381343 doi "https://doi.org/10.1055/s-2004-832716" @default.
• W2016381343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16088487" @default.
• W2016381343 hasPublicationYear "2004" @default.
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