Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016381877> ?p ?o ?g. }
- W2016381877 endingPage "8597" @default.
- W2016381877 startingPage "8593" @default.
- W2016381877 abstract "A primitive genetic code is thought to have encoded statistical, ambiguous proteins in which more than one amino acid was inserted at a given codon. The relative vitality of organisms bearing ambiguous proteins and the kinds of pressures that forced development of the highly specific modern genetic code are unknown. Previous work demonstrated that, in the absence of selective pressure, enforced ambiguity in cells leads to death or to sequence reversion to eliminate the ambiguous phenotype. Here, we report the creation of a nonreverting strain of bacteria that produced statistical proteins. Ablating the editing activity of isoleucyl-tRNA synthetase resulted in an ambiguous code in which, through supplementation of a limited supply of isoleucine with an alternative amino acid that was noncoding, the mutant generating statistical proteins was favored over the wild-type isogenic strain. Such organisms harboring statistical proteins could have had an enhanced adaptive capacity and could have played an important role in the early development of living systems." @default.
- W2016381877 created "2016-06-24" @default.
- W2016381877 creator A5004096613 @default.
- W2016381877 creator A5008315434 @default.
- W2016381877 creator A5013938980 @default.
- W2016381877 creator A5026856074 @default.
- W2016381877 creator A5046678505 @default.
- W2016381877 creator A5047965853 @default.
- W2016381877 creator A5050403641 @default.
- W2016381877 creator A5053308564 @default.
- W2016381877 creator A5088634712 @default.
- W2016381877 date "2004-05-26" @default.
- W2016381877 modified "2023-10-11" @default.
- W2016381877 title "Artificially ambiguous genetic code confers growth yield advantage" @default.
- W2016381877 cites W146967459 @default.
- W2016381877 cites W1480195325 @default.
- W2016381877 cites W1555471169 @default.
- W2016381877 cites W1573063310 @default.
- W2016381877 cites W1631484173 @default.
- W2016381877 cites W1728624194 @default.
- W2016381877 cites W1805730948 @default.
- W2016381877 cites W1923250545 @default.
- W2016381877 cites W1938326461 @default.
- W2016381877 cites W1972727312 @default.
- W2016381877 cites W1979414125 @default.
- W2016381877 cites W1981008283 @default.
- W2016381877 cites W1984288173 @default.
- W2016381877 cites W1985888036 @default.
- W2016381877 cites W1992401304 @default.
- W2016381877 cites W1995143868 @default.
- W2016381877 cites W1999151188 @default.
- W2016381877 cites W2004416250 @default.
- W2016381877 cites W2007239250 @default.
- W2016381877 cites W2011769650 @default.
- W2016381877 cites W2023737941 @default.
- W2016381877 cites W2044865929 @default.
- W2016381877 cites W2053811117 @default.
- W2016381877 cites W2066669437 @default.
- W2016381877 cites W2082846797 @default.
- W2016381877 cites W2083627310 @default.
- W2016381877 cites W2084022370 @default.
- W2016381877 cites W2089269422 @default.
- W2016381877 cites W2140885472 @default.
- W2016381877 cites W2160084442 @default.
- W2016381877 cites W2164509827 @default.
- W2016381877 cites W2167485371 @default.
- W2016381877 doi "https://doi.org/10.1073/pnas.0402893101" @default.
- W2016381877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/423239" @default.
- W2016381877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15163798" @default.
- W2016381877 hasPublicationYear "2004" @default.
- W2016381877 type Work @default.
- W2016381877 sameAs 2016381877 @default.
- W2016381877 citedByCount "65" @default.
- W2016381877 countsByYear W20163818772012 @default.
- W2016381877 countsByYear W20163818772013 @default.
- W2016381877 countsByYear W20163818772014 @default.
- W2016381877 countsByYear W20163818772015 @default.
- W2016381877 countsByYear W20163818772016 @default.
- W2016381877 countsByYear W20163818772017 @default.
- W2016381877 countsByYear W20163818772018 @default.
- W2016381877 countsByYear W20163818772019 @default.
- W2016381877 countsByYear W20163818772020 @default.
- W2016381877 countsByYear W20163818772021 @default.
- W2016381877 countsByYear W20163818772022 @default.
- W2016381877 countsByYear W20163818772023 @default.
- W2016381877 crossrefType "journal-article" @default.
- W2016381877 hasAuthorship W2016381877A5004096613 @default.
- W2016381877 hasAuthorship W2016381877A5008315434 @default.
- W2016381877 hasAuthorship W2016381877A5013938980 @default.
- W2016381877 hasAuthorship W2016381877A5026856074 @default.
- W2016381877 hasAuthorship W2016381877A5046678505 @default.
- W2016381877 hasAuthorship W2016381877A5047965853 @default.
- W2016381877 hasAuthorship W2016381877A5050403641 @default.
- W2016381877 hasAuthorship W2016381877A5053308564 @default.
- W2016381877 hasAuthorship W2016381877A5088634712 @default.
- W2016381877 hasBestOaLocation W20163818771 @default.
- W2016381877 hasConcept C104317684 @default.
- W2016381877 hasConcept C105702510 @default.
- W2016381877 hasConcept C10853874 @default.
- W2016381877 hasConcept C127716648 @default.
- W2016381877 hasConcept C143065580 @default.
- W2016381877 hasConcept C153957851 @default.
- W2016381877 hasConcept C199360897 @default.
- W2016381877 hasConcept C2776580952 @default.
- W2016381877 hasConcept C2777305461 @default.
- W2016381877 hasConcept C2777573094 @default.
- W2016381877 hasConcept C2778022156 @default.
- W2016381877 hasConcept C2780522230 @default.
- W2016381877 hasConcept C41008148 @default.
- W2016381877 hasConcept C501734568 @default.
- W2016381877 hasConcept C515207424 @default.
- W2016381877 hasConcept C54355233 @default.
- W2016381877 hasConcept C67705224 @default.
- W2016381877 hasConcept C70721500 @default.
- W2016381877 hasConcept C70883133 @default.
- W2016381877 hasConcept C86803240 @default.
- W2016381877 hasConceptScore W2016381877C104317684 @default.
- W2016381877 hasConceptScore W2016381877C105702510 @default.