Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016385391> ?p ?o ?g. }
- W2016385391 abstract "Genetic studies on PARK genes have identified dysfunction in proteasomal, lysosomal, and mitochondrial enzymes as pathogenic for Parkinson's disease (PD). We review the role of these and similar enzymes in mediating innate immune signaling. In particular, we have identified that a number of PARK gene products as well as other enzymes have roles in innate immune signaling as well as DNA repair and regulation, ubiquitination, mitochondrial functioning, and synaptic trafficking. PD enzymatic dysfunction is likely to contribute to inadequate innate immune responses to a variety of extra- and intra-cellular stimuli, with a number of the innate immunity related enzymes found in the characteristic Lewy body pathology of PD. The decrease in innate immunity in PD is associated with an increase in markers of adaptive immunity, and recent GWAS studies have identified variants in human leukocyte antigen region as associated with late-onset sporadic PD (Hamza et al., 2010; Hill-Burns et al., 2011). Intriguing new data also suggest that peripheral immune responses may be involved, giving some potential to alleviate such peripheral dysfunction more directly in patients with PD. It is now important to identify the cell type specific immune responses contributing to the initial changes that occur in PD, as well as to the propagating immune responses important for the progression of PD pathology between cells and within the brain. Overall, a complex interplay between different types of immunity appear to be involved in the underlying pathology of PD." @default.
- W2016385391 created "2016-06-24" @default.
- W2016385391 creator A5011336092 @default.
- W2016385391 creator A5047141421 @default.
- W2016385391 date "2012-01-01" @default.
- W2016385391 modified "2023-10-16" @default.
- W2016385391 title "Aspects of Innate Immunity and Parkinson’s Disease" @default.
- W2016385391 cites W1259614189 @default.
- W2016385391 cites W1504584187 @default.
- W2016385391 cites W1507318381 @default.
- W2016385391 cites W152231878 @default.
- W2016385391 cites W1649631662 @default.
- W2016385391 cites W1967640115 @default.
- W2016385391 cites W1968957266 @default.
- W2016385391 cites W1968998365 @default.
- W2016385391 cites W1971776963 @default.
- W2016385391 cites W1974924674 @default.
- W2016385391 cites W1977105782 @default.
- W2016385391 cites W1979096652 @default.
- W2016385391 cites W1979940710 @default.
- W2016385391 cites W1981942880 @default.
- W2016385391 cites W1983326322 @default.
- W2016385391 cites W1984136850 @default.
- W2016385391 cites W1986188355 @default.
- W2016385391 cites W1987183038 @default.
- W2016385391 cites W1987634218 @default.
- W2016385391 cites W1990195639 @default.
- W2016385391 cites W1992040739 @default.
- W2016385391 cites W1994391392 @default.
- W2016385391 cites W1995577291 @default.
- W2016385391 cites W1997592403 @default.
- W2016385391 cites W1998878076 @default.
- W2016385391 cites W1999031334 @default.
- W2016385391 cites W2004336750 @default.
- W2016385391 cites W2004698905 @default.
- W2016385391 cites W2004726009 @default.
- W2016385391 cites W2005091026 @default.
- W2016385391 cites W2007684143 @default.
- W2016385391 cites W2009769910 @default.
- W2016385391 cites W2012347071 @default.
- W2016385391 cites W2012844038 @default.
- W2016385391 cites W2015640363 @default.
- W2016385391 cites W2017061287 @default.
- W2016385391 cites W2017286832 @default.
- W2016385391 cites W2022421870 @default.
- W2016385391 cites W2025412364 @default.
- W2016385391 cites W2027422916 @default.
- W2016385391 cites W2029473602 @default.
- W2016385391 cites W2031190164 @default.
- W2016385391 cites W2033448006 @default.
- W2016385391 cites W2033562377 @default.
- W2016385391 cites W2037331859 @default.
- W2016385391 cites W2038524016 @default.
- W2016385391 cites W2038726784 @default.
- W2016385391 cites W2039542458 @default.
- W2016385391 cites W2040462263 @default.
- W2016385391 cites W2044908785 @default.
- W2016385391 cites W2046484793 @default.
- W2016385391 cites W2056402897 @default.
- W2016385391 cites W2057225928 @default.
- W2016385391 cites W2057832589 @default.
- W2016385391 cites W2057913943 @default.
- W2016385391 cites W2058900484 @default.
- W2016385391 cites W2059261643 @default.
- W2016385391 cites W2061680483 @default.
- W2016385391 cites W2063511353 @default.
- W2016385391 cites W2066760606 @default.
- W2016385391 cites W2066943328 @default.
- W2016385391 cites W2067340670 @default.
- W2016385391 cites W2071670416 @default.
- W2016385391 cites W2074362914 @default.
- W2016385391 cites W2074397899 @default.
- W2016385391 cites W2074833985 @default.
- W2016385391 cites W2077360634 @default.
- W2016385391 cites W2078504890 @default.
- W2016385391 cites W2083922442 @default.
- W2016385391 cites W2085701543 @default.
- W2016385391 cites W2088211927 @default.
- W2016385391 cites W2089100941 @default.
- W2016385391 cites W2089822522 @default.
- W2016385391 cites W2091489434 @default.
- W2016385391 cites W2092462980 @default.
- W2016385391 cites W2097777783 @default.
- W2016385391 cites W2100894616 @default.
- W2016385391 cites W2101090646 @default.
- W2016385391 cites W2101362932 @default.
- W2016385391 cites W2104912043 @default.
- W2016385391 cites W2106579247 @default.
- W2016385391 cites W2107513655 @default.
- W2016385391 cites W2108578752 @default.
- W2016385391 cites W2113010696 @default.
- W2016385391 cites W2117327528 @default.
- W2016385391 cites W2118118182 @default.
- W2016385391 cites W2121516058 @default.
- W2016385391 cites W2123184492 @default.
- W2016385391 cites W2124116502 @default.
- W2016385391 cites W2124367828 @default.
- W2016385391 cites W2125284469 @default.
- W2016385391 cites W2126549314 @default.
- W2016385391 cites W2129248872 @default.