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• W2016389457 abstract "Aims To evaluate the accuracy of different techniques of MRI steatosis quantification, based on histological grading and quantification of liver steatosis. Patients and methods Twenty-three patients (21 with nonalcoholic fatty liver disease and two controls) were included. Steatosis was evaluated in liver specimens using histological grading (five grades) and steatosis area (% of liver surface) was computed using an inhouse automated image analysis. The following five MRI quantification techniques were performed: two-point Dixon, three-point Dixon, DUAL, spin echo method and a new technique called multi-echo gradient-echo (MFGRE). Interobserver (two observers) and intersite (three different liver sites) agreements were evaluated for the two best-performing methods. Results Steatosis area was correlated with steatosis grade: Rs (Spearman coefficient)=0.82, P value of less than 0.001. The steatosis area was significantly different between S0–S2 and S3–S4 grades: 4.2±2.4 versus 16.4±8.9% (P<0.001). Correlations between the MRI techniques and steatosis area (or grading) were: MFGRE, Rs=0.72 (0.78); spin echo method, Rs=0.72 (0.76); DUAL, Rs=0.71 (0.76); two-point Dixon, Rs=0.71 (0.75); three-point Dixon, Rs=0.67 (0.77). Interobserver (Ric=0.99) and intersite (Ric=0.97) agreements were excellent for the liver steatosis measurement by MFGRE. The noninvasive diagnosis of the steatosis area was improved by adding blood markers like ALT and triglycerides to MFGRE (aR2: 0.805). Conclusion MRI, and in particular the MFGRE method, provides accurate and automatic quantification for the noninvasive evaluation of liver steatosis, either as a single measurement or in combination with blood variables." @default.
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• W2016389457 date "2010-08-01" @default.
• W2016389457 modified "2023-10-18" @default.
• W2016389457 title "Noninvasive liver steatosis quantification using MRI techniques combined with blood markers" @default.
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• W2016389457 doi "https://doi.org/10.1097/meg.0b013e32833775fb" @default.
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