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• W2016390086 abstract "MicroRNAs play key regulatory roles in cellular processes including neurogenesis, synapse development and plasticity in the brain. Psychostimulants induce strong neuroadaptive changes through a surfeit of gene regulatory mechanisms leading to addiction. MicroRNA profiling for identifying miRNAs regulating cocaine-induced, plasticity-related genes revealed significant regulation of a set of miRNAs upon cocaine administration, especially let-7d, miR-181a and the brain-specific miR-124. These miRNAs target many genes involved in cocaine addiction. Precursor and mature miRNA quantification by qRT-PCR showed that miR-124 and let-7d are significantly downregulated, whereas miR-181a is induced in the mesolimbic dopaminergic system under chronic cocaine administration. Results were confirmed by in situ hybridization, Northern blots, FISH analysis and RNase protection assay. Using lentiviral-mediated miRNA expression, we show a significant downregulation of BDNF and D3R both at mRNA and protein levels by miR-124 and let-7d, respectively. Our data suggest that miR-124, let-7d and miR-181a may be involved in a complex feedback loop with cocaine-responsive plasticity genes, highlighting the possibility that some miRNAs are key regulators of the reward circuit and may be implicated in addiction." @default.
• W2016390086 created "2016-06-24" @default.
• W2016390086 creator A5010330116 @default.
• W2016390086 creator A5067189977 @default.
• W2016390086 date "2009-11-01" @default.
• W2016390086 modified "2023-09-30" @default.
• W2016390086 title "microRNAs miR-124, let-7d and miR-181a regulate Cocaine-induced Plasticity" @default.
• W2016390086 cites W144423133 @default.
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• W2016390086 cites W1516514579 @default.
• W2016390086 cites W1584433563 @default.
• W2016390086 cites W1606692946 @default.
• W2016390086 cites W1634913020 @default.
• W2016390086 cites W1820118415 @default.
• W2016390086 cites W1965306643 @default.
• W2016390086 cites W1968300632 @default.
• W2016390086 cites W1970998345 @default.
• W2016390086 cites W1973599627 @default.
• W2016390086 cites W1980492403 @default.
• W2016390086 cites W1981506621 @default.
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• W2016390086 cites W1992941735 @default.
• W2016390086 cites W1994662769 @default.
• W2016390086 cites W2004362903 @default.
• W2016390086 cites W2007689138 @default.
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• W2016390086 cites W2018312069 @default.
• W2016390086 cites W2019028138 @default.
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• W2016390086 cites W2032984680 @default.
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• W2016390086 cites W2043386629 @default.
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• W2016390086 cites W2045275016 @default.
• W2016390086 cites W2048858599 @default.
• W2016390086 cites W2049796382 @default.
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• W2016390086 cites W2069243189 @default.
• W2016390086 cites W2072367937 @default.
• W2016390086 cites W2078518864 @default.
• W2016390086 cites W2086498488 @default.
• W2016390086 cites W2091811407 @default.
• W2016390086 cites W2094284473 @default.
• W2016390086 cites W2097087580 @default.
• W2016390086 cites W2097490871 @default.
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• W2016390086 doi "https://doi.org/10.1016/j.mcn.2009.08.009" @default.
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