FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016392255> ?p ?o ?g. }

• W2016392255 endingPage "47" @default.
• W2016392255 startingPage "34" @default.
• W2016392255 abstract "This study aimed at elucidating the in vivo metabolism of nicotine both with and without inhibitors of nicotine metabolism. Second, the role of mouse CYP2A5 in nicotine oxidation in vitro was studied as such information is needed to assess whether the mouse is a suitable model for studying chemical inhibitors of the human CYP2A6. The oxidation of nicotine to cotinine was measured and the ability of various inhibitors to modify this reaction was determined. Nicotine and various inhibitors were co-administered to CD2F1 mice, and nicotine and urinary levels of nicotine and four metabolites were determined. In mouse liver microsomes anti-CYP2A5 antibody and known chemical inhibitors of the CYP2A5 enzyme blocked cotinine formation by 85–100%, depending on the pre-treatment of the mice. The amount of trans-3-hydroxycotine was five times higher than cotinine N-oxide, and ten times higher than nicotine N-1-oxide and cotinine. Methoxsalen, an irreversible inhibitor of CYP2A5, significantly reduced the metabolic elimination of nicotine in vivo, but the reversible inhibitors had no effect. It is concluded that the metabolism of nicotine in mouse is very similar to that in man and, therefore, that the mouse is a suitable model for testing novel chemical inhibitors of human CYP2A6." @default.
• W2016392255 created "2016-06-24" @default.
• W2016392255 creator A5015580338 @default.
• W2016392255 creator A5024765402 @default.
• W2016392255 creator A5046556611 @default.
• W2016392255 creator A5058041458 @default.
• W2016392255 creator A5070076962 @default.
• W2016392255 creator A5077018565 @default.
• W2016392255 creator A5091784289 @default.
• W2016392255 date "2008-01-01" @default.
• W2016392255 modified "2023-09-26" @default.
• W2016392255 title "Nicotine metabolism and urinary elimination in mouse:<i>in vitro</i>and<i>in vivo</i>" @default.
• W2016392255 cites W1531891379 @default.
• W2016392255 cites W1593444153 @default.
• W2016392255 cites W1801981734 @default.
• W2016392255 cites W1964374446 @default.
• W2016392255 cites W1980224195 @default.
• W2016392255 cites W1985687417 @default.
• W2016392255 cites W1987867942 @default.
• W2016392255 cites W1996485240 @default.
• W2016392255 cites W2006629780 @default.
• W2016392255 cites W2022811442 @default.
• W2016392255 cites W2036991393 @default.
• W2016392255 cites W2045705381 @default.
• W2016392255 cites W2046814864 @default.
• W2016392255 cites W2052017457 @default.
• W2016392255 cites W2053996826 @default.
• W2016392255 cites W2058073836 @default.
• W2016392255 cites W2059978315 @default.
• W2016392255 cites W2060286371 @default.
• W2016392255 cites W2060938572 @default.
• W2016392255 cites W2069259030 @default.
• W2016392255 cites W2071583942 @default.
• W2016392255 cites W2072505941 @default.
• W2016392255 cites W2098436801 @default.
• W2016392255 cites W2106235111 @default.
• W2016392255 cites W2121557735 @default.
• W2016392255 cites W2121888318 @default.
• W2016392255 cites W2125937217 @default.
• W2016392255 cites W2133617154 @default.
• W2016392255 cites W2155904320 @default.
• W2016392255 cites W2160280522 @default.
• W2016392255 cites W2169463741 @default.
• W2016392255 cites W2180704072 @default.
• W2016392255 cites W4232534952 @default.
• W2016392255 doi "https://doi.org/10.1080/00498250701708539" @default.
• W2016392255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18098062" @default.
• W2016392255 hasPublicationYear "2008" @default.
• W2016392255 type Work @default.
• W2016392255 sameAs 2016392255 @default.
• W2016392255 citedByCount "25" @default.
• W2016392255 countsByYear W20163922552012 @default.
• W2016392255 countsByYear W20163922552013 @default.
• W2016392255 countsByYear W20163922552015 @default.
• W2016392255 countsByYear W20163922552016 @default.
• W2016392255 countsByYear W20163922552017 @default.
• W2016392255 countsByYear W20163922552018 @default.
• W2016392255 countsByYear W20163922552019 @default.
• W2016392255 countsByYear W20163922552020 @default.
• W2016392255 countsByYear W20163922552021 @default.
• W2016392255 countsByYear W20163922552022 @default.
• W2016392255 countsByYear W20163922552023 @default.
• W2016392255 crossrefType "journal-article" @default.
• W2016392255 hasAuthorship W2016392255A5015580338 @default.
• W2016392255 hasAuthorship W2016392255A5024765402 @default.
• W2016392255 hasAuthorship W2016392255A5046556611 @default.
• W2016392255 hasAuthorship W2016392255A5058041458 @default.
• W2016392255 hasAuthorship W2016392255A5070076962 @default.
• W2016392255 hasAuthorship W2016392255A5077018565 @default.
• W2016392255 hasAuthorship W2016392255A5091784289 @default.
• W2016392255 hasConcept C126322002 @default.
• W2016392255 hasConcept C150903083 @default.
• W2016392255 hasConcept C185592680 @default.
• W2016392255 hasConcept C196013638 @default.
• W2016392255 hasConcept C202751555 @default.
• W2016392255 hasConcept C207001950 @default.
• W2016392255 hasConcept C2776319443 @default.
• W2016392255 hasConcept C2779547902 @default.
• W2016392255 hasConcept C55493867 @default.
• W2016392255 hasConcept C62231903 @default.
• W2016392255 hasConcept C71924100 @default.
• W2016392255 hasConcept C86745063 @default.
• W2016392255 hasConcept C86803240 @default.
• W2016392255 hasConcept C87644729 @default.
• W2016392255 hasConcept C98274493 @default.
• W2016392255 hasConceptScore W2016392255C126322002 @default.
• W2016392255 hasConceptScore W2016392255C150903083 @default.
• W2016392255 hasConceptScore W2016392255C185592680 @default.
• W2016392255 hasConceptScore W2016392255C196013638 @default.
• W2016392255 hasConceptScore W2016392255C202751555 @default.
• W2016392255 hasConceptScore W2016392255C207001950 @default.
• W2016392255 hasConceptScore W2016392255C2776319443 @default.
• W2016392255 hasConceptScore W2016392255C2779547902 @default.
• W2016392255 hasConceptScore W2016392255C55493867 @default.
• W2016392255 hasConceptScore W2016392255C62231903 @default.
• W2016392255 hasConceptScore W2016392255C71924100 @default.
• W2016392255 hasConceptScore W2016392255C86745063 @default.
• W2016392255 hasConceptScore W2016392255C86803240 @default.

• next