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- W2016392282 abstract "Novamethymycin (9), a novel macrolide antibiotic, was isolated from Streptomyces venezuelae, the producer of methymycin (4) and neomethymycin (5). Spectroscopic analysis of 9 indicated that it is highly related to 4 and 5 but contains hydroxy groups at both C-10 and C-12 on the macrolactone ring. Bioconversion studies using the PikC cytochrome P450 hydroxylase demonstrated that 4 is converted to 9, further broadening the remarkable substrate flexibility of this enzyme." @default.
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- W2016392282 date "2001-10-19" @default.
- W2016392282 modified "2023-09-27" @default.
- W2016392282 title "Isolation and Structure Determination of Novamethymycin, a New Bioactive Metabolite of the Methymycin Biosynthetic Pathway in <i>Streptomyces </i><i>v</i><i>enezuelae</i>" @default.
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- W2016392282 doi "https://doi.org/10.1021/np010146r" @default.
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