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- W2016394052 abstract "Sound data support the concept that in atherosclerosis, inflammation and dyslipidemia intersect each other and that irrespective of the initiator, both participate from the early stages to the ultimate fate of the atheromatous plaque. The two partakers manoeuvre a vicious circle in atheroma formation: dyslipidaemia triggers an inflammatory process and inflammation elicits dyslipidaemia. Independent of the initial cause, the atherosclerotic lesions occur focally, in particular arterial-susceptible sites, by a process that, although continuous, can be arbitrarily divided into a sequence of consecutive stages that lead from fatty streak to the fibro-lipid plaque and ultimately to plaque rupture and thrombosis. In the process, the initial event is a change in endothelial cells (EC) constitutive properties. Then, the molecular alarm signals send by dysfunctional EC are decoded by specific blood immune cells (monocytes, T lymphocytes, neutrophils, mast cells) and by the resident vascular cells, that respond by initiating a robust inflammatory process, in which the cells and the factors they secrete hasten the atheroma development. Direct and indirect crosstalk between the cells housed within the nascent plaque, complemented by the increase in risk factors of atherosclerosis lead to atheroma development and outcome. The initial inflammatory response can be regarded as a defense/protective reaction mechanism, but its further amplification, speeds up atherosclerosis. In this review, we provide an overview on the role of inflammation and dyslipidaemia and their intersection in atherogenesis. The data may add to the foundation of a novel attitude in the diagnosis and treatment of atherosclerosis." @default.
- W2016394052 created "2016-06-24" @default.
- W2016394052 creator A5023507718 @default.
- W2016394052 creator A5073391419 @default.
- W2016394052 date "2012-08-23" @default.
- W2016394052 modified "2023-10-16" @default.
- W2016394052 title "Inflammation in atherosclerosis: a cause or a result of vascular disorders?" @default.
- W2016394052 cites W1489614500 @default.
- W2016394052 cites W1536417691 @default.
- W2016394052 cites W1552829599 @default.
- W2016394052 cites W1574373575 @default.
- W2016394052 cites W1964147539 @default.
- W2016394052 cites W1964369726 @default.
- W2016394052 cites W1967279046 @default.
- W2016394052 cites W1968148355 @default.
- W2016394052 cites W196835504 @default.
- W2016394052 cites W1970295969 @default.
- W2016394052 cites W1978033197 @default.
- W2016394052 cites W1984378291 @default.
- W2016394052 cites W1986912541 @default.
- W2016394052 cites W1989000730 @default.
- W2016394052 cites W1989722258 @default.
- W2016394052 cites W1993184147 @default.
- W2016394052 cites W1996629582 @default.
- W2016394052 cites W1996866382 @default.
- W2016394052 cites W1997458315 @default.
- W2016394052 cites W2002077734 @default.
- W2016394052 cites W2002771508 @default.
- W2016394052 cites W2003943211 @default.
- W2016394052 cites W2004441765 @default.
- W2016394052 cites W2005760229 @default.
- W2016394052 cites W2008960002 @default.
- W2016394052 cites W2011276033 @default.
- W2016394052 cites W2012085736 @default.
- W2016394052 cites W2012474849 @default.
- W2016394052 cites W2014759041 @default.
- W2016394052 cites W2015141049 @default.
- W2016394052 cites W2028992794 @default.
- W2016394052 cites W2029471567 @default.
- W2016394052 cites W2031575410 @default.
- W2016394052 cites W2032811951 @default.
- W2016394052 cites W2033061317 @default.
- W2016394052 cites W2036746876 @default.
- W2016394052 cites W2048380290 @default.
- W2016394052 cites W2051013246 @default.
- W2016394052 cites W2054435322 @default.
- W2016394052 cites W2060198143 @default.
- W2016394052 cites W2061287785 @default.
- W2016394052 cites W2063966443 @default.
- W2016394052 cites W2069808711 @default.
- W2016394052 cites W2072699958 @default.
- W2016394052 cites W2074499846 @default.
- W2016394052 cites W2075256894 @default.
- W2016394052 cites W2079307913 @default.
- W2016394052 cites W2082492640 @default.
- W2016394052 cites W2083441673 @default.
- W2016394052 cites W2085804112 @default.
- W2016394052 cites W2088963850 @default.
- W2016394052 cites W2090557388 @default.
- W2016394052 cites W2090687004 @default.
- W2016394052 cites W2091188664 @default.
- W2016394052 cites W2094199250 @default.
- W2016394052 cites W2096626379 @default.
- W2016394052 cites W2097097751 @default.
- W2016394052 cites W2100927341 @default.
- W2016394052 cites W2105169620 @default.
- W2016394052 cites W2105301301 @default.
- W2016394052 cites W2105594104 @default.
- W2016394052 cites W2107967984 @default.
- W2016394052 cites W2109807835 @default.
- W2016394052 cites W2113186517 @default.
- W2016394052 cites W2113345760 @default.
- W2016394052 cites W2113485831 @default.
- W2016394052 cites W2113501575 @default.
- W2016394052 cites W2114022169 @default.
- W2016394052 cites W2114381479 @default.
- W2016394052 cites W2115045550 @default.
- W2016394052 cites W2121149365 @default.
- W2016394052 cites W2124444196 @default.
- W2016394052 cites W2125674758 @default.
- W2016394052 cites W2128514908 @default.
- W2016394052 cites W2129403909 @default.
- W2016394052 cites W2132014308 @default.
- W2016394052 cites W2132190297 @default.
- W2016394052 cites W2134667046 @default.
- W2016394052 cites W2136208700 @default.
- W2016394052 cites W2137951377 @default.
- W2016394052 cites W2138287637 @default.
- W2016394052 cites W2138893291 @default.
- W2016394052 cites W2140066110 @default.
- W2016394052 cites W2145865564 @default.
- W2016394052 cites W2146917818 @default.
- W2016394052 cites W2147155927 @default.
- W2016394052 cites W2148923374 @default.
- W2016394052 cites W2148928213 @default.
- W2016394052 cites W2151483213 @default.
- W2016394052 cites W2155939240 @default.
- W2016394052 cites W2159904559 @default.