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• W2016395764 abstract "It is assumed that the increased incidence of neoplastic pathologies with advancing age is correlated with the immunosenescence and with the altered immune-surveillance. The present study was aimed at evaluating the role of the immunocompetent system and immunosenescence in carcinogenesis. A pool of 99 subjects (38 females, 61 males) has been analyzed in three groups as follows. Group A: 51 elderly subjects with cancer (16 females and 35 males, average age 73.7±7.5 years). Group B: 24 young subjects with cancer (12 females, 12 males, average age 49.5±10.3 years). Group C: 24 elderly subjects without any clinical evidence of cancer (10 females, 14 males, average age 74.6±6.3 years). Hemo-chromocytometric analysis and cytofluorimetric typifying have been performed in all subjects. A decrease of T (CD3+)-lymphocytes has been observed in group A, if compared to group B (P<0.007), and to group C (P<0.01), The T (CD4+)-lymphocytes were fewer in group A, than in group C (P<0.004), and also the NK cells showed the same trend (P<0.002). The numbers of leukocytes and monocytes increased in group A compared to group C (P<0.01 and P<0.004, respectively). Red cell numbers, hemoglobin and hematocrit values were lower in group A than in group B (P<0.03, P<0.03, P<0.01, respectively), and also than in group C (P<0.007, P<0.001, P<0.01, respectively), The results demonstrate that the alterations of the immunocompetent cells, particularly of the T-cell pool, may play an important role in the carcinogenesis of the elderly." @default.
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• W2016395764 date "2003-01-01" @default.
• W2016395764 modified "2023-09-24" @default.
• W2016395764 title "Alterations of the lymphocytic set-up in elderly patients with cancer" @default.
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• W2016395764 doi "https://doi.org/10.1016/s0167-4943(02)00053-5" @default.
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