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- W2016396893 abstract "Estrogen has been shown to augment nitric oxide production in a variety of vascular beds. Hyperinsulinemia causes vasodilatation through a nitric oxide-mediated mechanism. Our goal was to determine the effect of the menstrual cycle and ovarian hormone suppression with leuprolide acetate on calf blood flow under basal and insulin-stimulated conditions. Prospective, randomized, placebo-controlled trial. Twelve lean, premenopausal women with regular cycles (28±1 years) had calf blood flow determined by plethysmography during the early follicular and midluteal phases of the menstrual cycle under basal, postabsorptive conditions and during hyperinsulinemic euglycemic clamp with amino acid infusion. Patients were then randomized to an eight week course of leuprolide acetate (3.75 mg, n=6) or placebo (n=6) and retested. At baseline, the leuprolide and placebo groups were similar in age, height, weight and body composition and no changes were noted in these variables with cycle phase or treatment. Insulin and amino acid levels during the euglycemic clamp were similar between the two groups at all time points. There were no changes in basal calf blood flow (1.65±0.09 %/min. vs. 1.73±0.16 %/min) or insulin-stimulated vasodilatation (35±7 % vs. 38±8 %) during the follicular versus luteal phases of the menstrual cycle, respectively. Thus, blood flow data for follicular and luteal phases were averaged. Neither basal blood flow (1.68±0.13 %/min. to 1.69±0.15 %/min. vs. 1.69±0.21 %/min. to 1.64±0.14 %/min.) nor insulin-mediated vasodilatation (49±10 % to 40±10 % vs. 24± 3% to 26± 13%) changed with leuprolide treatment compared to placebo. Ovarian hormone deficiency induced by GnRH analog does not affect calf blood flow under basal or insulin-stimulated conditions." @default.
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- W2016396893 date "2005-09-01" @default.
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- W2016396893 title "Basal and Insulin-Stimulated Calf Blood Flow Does Not Change With Ovarian Hormone Suppression" @default.
- W2016396893 doi "https://doi.org/10.1016/j.fertnstert.2005.07.589" @default.
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