Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016397148> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2016397148 endingPage "1379" @default.
- W2016397148 startingPage "1374" @default.
- W2016397148 abstract "Plasma low-density lipoprotein-cholesterol (LDL-C) is mainly taken up and cleared by the hepatocellular LDL receptor (LDL-R). LDL-R gene expression is regulated by the sterol regulatory element binding proteins (SREBPs). Previous studies have shown that curcumin reduces plasma LDL-C and has hypolipidemic and anti-atherosclerotic effects. Herein, we investigated the effect of curcumin on LDL-R expression and its molecular mechanism in HepG2 cells. Curcumin increased LDL-R expression (mRNA and protein) and the resultant uptake of DiI-LDL in a dose- and time-dependent manner. Using a GFP reporter system in a transfected HepG2/SRE-GFP cell line, we found that curcumin activated the sterol regulatory element of the LDL-R promoter. In HepG2/Insig2 cells, curcumin reversed the inhibition of LDL-R expression induced by Insig2 overexpression. These data demonstrate that curcumin increases LDL-R protein expression and uptake activity via the SREBPs pathway. These findings contribute to our further understanding of the cholesterol-lowering and anti-atherosclerotic effects of curcumin." @default.
- W2016397148 created "2016-06-24" @default.
- W2016397148 creator A5021409868 @default.
- W2016397148 creator A5030328823 @default.
- W2016397148 creator A5037782994 @default.
- W2016397148 creator A5045200600 @default.
- W2016397148 creator A5055886823 @default.
- W2016397148 creator A5057720547 @default.
- W2016397148 date "2008-08-14" @default.
- W2016397148 modified "2023-09-27" @default.
- W2016397148 title "Curcumin Up-Regulates LDL Receptor Expression via the Sterol Regulatory Element Pathway in HepG2 Cells" @default.
- W2016397148 doi "https://doi.org/10.1055/s-2008-1081316" @default.
- W2016397148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18704882" @default.
- W2016397148 hasPublicationYear "2008" @default.
- W2016397148 type Work @default.
- W2016397148 sameAs 2016397148 @default.
- W2016397148 citedByCount "36" @default.
- W2016397148 countsByYear W20163971482012 @default.
- W2016397148 countsByYear W20163971482013 @default.
- W2016397148 countsByYear W20163971482014 @default.
- W2016397148 countsByYear W20163971482015 @default.
- W2016397148 countsByYear W20163971482017 @default.
- W2016397148 countsByYear W20163971482018 @default.
- W2016397148 countsByYear W20163971482019 @default.
- W2016397148 countsByYear W20163971482020 @default.
- W2016397148 countsByYear W20163971482021 @default.
- W2016397148 countsByYear W20163971482022 @default.
- W2016397148 crossrefType "journal-article" @default.
- W2016397148 hasAuthorship W2016397148A5021409868 @default.
- W2016397148 hasAuthorship W2016397148A5030328823 @default.
- W2016397148 hasAuthorship W2016397148A5037782994 @default.
- W2016397148 hasAuthorship W2016397148A5045200600 @default.
- W2016397148 hasAuthorship W2016397148A5055886823 @default.
- W2016397148 hasAuthorship W2016397148A5057720547 @default.
- W2016397148 hasConcept C170493617 @default.
- W2016397148 hasConcept C185592680 @default.
- W2016397148 hasConcept C2778163477 @default.
- W2016397148 hasConcept C2778250585 @default.
- W2016397148 hasConcept C2778718757 @default.
- W2016397148 hasConcept C2779620165 @default.
- W2016397148 hasConcept C2780072125 @default.
- W2016397148 hasConcept C2780948078 @default.
- W2016397148 hasConcept C43554185 @default.
- W2016397148 hasConcept C55493867 @default.
- W2016397148 hasConcept C85051948 @default.
- W2016397148 hasConcept C86803240 @default.
- W2016397148 hasConcept C98274493 @default.
- W2016397148 hasConceptScore W2016397148C170493617 @default.
- W2016397148 hasConceptScore W2016397148C185592680 @default.
- W2016397148 hasConceptScore W2016397148C2778163477 @default.
- W2016397148 hasConceptScore W2016397148C2778250585 @default.
- W2016397148 hasConceptScore W2016397148C2778718757 @default.
- W2016397148 hasConceptScore W2016397148C2779620165 @default.
- W2016397148 hasConceptScore W2016397148C2780072125 @default.
- W2016397148 hasConceptScore W2016397148C2780948078 @default.
- W2016397148 hasConceptScore W2016397148C43554185 @default.
- W2016397148 hasConceptScore W2016397148C55493867 @default.
- W2016397148 hasConceptScore W2016397148C85051948 @default.
- W2016397148 hasConceptScore W2016397148C86803240 @default.
- W2016397148 hasConceptScore W2016397148C98274493 @default.
- W2016397148 hasIssue "11" @default.
- W2016397148 hasLocation W20163971481 @default.
- W2016397148 hasLocation W20163971482 @default.
- W2016397148 hasOpenAccess W2016397148 @default.
- W2016397148 hasPrimaryLocation W20163971481 @default.
- W2016397148 hasRelatedWork W1523134239 @default.
- W2016397148 hasRelatedWork W2016397148 @default.
- W2016397148 hasRelatedWork W2018377654 @default.
- W2016397148 hasRelatedWork W2087652827 @default.
- W2016397148 hasRelatedWork W2112233943 @default.
- W2016397148 hasRelatedWork W2136512187 @default.
- W2016397148 hasRelatedWork W2578353034 @default.
- W2016397148 hasRelatedWork W2735001212 @default.
- W2016397148 hasRelatedWork W3083227284 @default.
- W2016397148 hasRelatedWork W2184654009 @default.
- W2016397148 hasVolume "74" @default.
- W2016397148 isParatext "false" @default.
- W2016397148 isRetracted "false" @default.
- W2016397148 magId "2016397148" @default.
- W2016397148 workType "article" @default.