FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016400514> ?p ?o ?g. }

• W2016400514 endingPage "1266" @default.
• W2016400514 startingPage "1257" @default.
• W2016400514 abstract "Human microsomal epoxide hydrolase (HYL1) plays an important role in the detoxification of environmental compounds and drugs, such as the aromatic anticonvulsants phenytoin, carbamazepine, and phenobarbital, by converting their P450-generated epoxide metabolites into nontoxic diols. Recently, we have shown that a genetic defect altering the structure and function of the HYL1 protein is unlikely to be responsible for predisposing individuals to idiosyncratic hypersensitivity reactions from anticonvulsants. To evaluate the possible involvement of regulatory mechanisms, we used 5' rapid amplification of cDNA ends (RACE) and reverse transcription polymerase chain reaction (RT-PCR) to identify and characterize HYL1 5' cDNA ends. In addition to exon 1 (E1) previously isolated from a liver cDNA library, we isolated four new exons (E1-a, E1-c, E1-d, and E1-e) from various tissues. E1 was always directly connected to exon 2 (E2) where the translation start codon is located. E1-a, E1-c E1-d, and E1-e are alternatively spliced to E2, having either E1-a or E1-a' (a truncated form of E1-a) at the 5' end of their respective transcript. Genomic data indicate that exons E1-a and E1-c are located at least 7 kb upstream from E1. Furthermore, we demonstrated a tissue-specific expression pattern for E1-containing mRNA species, whereas E1-a-containing transcripts appear to be expressed ubiquitously. Our results provide evidence that microsomal epoxide hydrolase is regulated by multiple untranslated exons flanked by tissue-specific promoters." @default.
• W2016400514 created "2016-06-24" @default.
• W2016400514 creator A5001681968 @default.
• W2016400514 creator A5060059504 @default.
• W2016400514 creator A5083587616 @default.
• W2016400514 date "1997-11-01" @default.
• W2016400514 modified "2023-10-12" @default.
• W2016400514 title "Tissue-Specific Expression and Alternative Splicing of Human Microsomal Epoxide Hydrolase" @default.
• W2016400514 cites W1526744579 @default.
• W2016400514 cites W1553425832 @default.
• W2016400514 cites W1554692773 @default.
• W2016400514 cites W1557658741 @default.
• W2016400514 cites W1732960356 @default.
• W2016400514 cites W1963576120 @default.
• W2016400514 cites W1975686293 @default.
• W2016400514 cites W1977285945 @default.
• W2016400514 cites W1981330976 @default.
• W2016400514 cites W1984636761 @default.
• W2016400514 cites W1993600509 @default.
• W2016400514 cites W2010033395 @default.
• W2016400514 cites W2010629576 @default.
• W2016400514 cites W2016879656 @default.
• W2016400514 cites W2017374476 @default.
• W2016400514 cites W2018075142 @default.
• W2016400514 cites W2021243296 @default.
• W2016400514 cites W2029158055 @default.
• W2016400514 cites W2033131060 @default.
• W2016400514 cites W2034496820 @default.
• W2016400514 cites W2041939624 @default.
• W2016400514 cites W2044523170 @default.
• W2016400514 cites W2047108847 @default.
• W2016400514 cites W2075255576 @default.
• W2016400514 cites W2077003408 @default.
• W2016400514 cites W2079198255 @default.
• W2016400514 cites W2080585092 @default.
• W2016400514 cites W2081917625 @default.
• W2016400514 cites W2082048404 @default.
• W2016400514 cites W2091655349 @default.
• W2016400514 cites W2092547974 @default.
• W2016400514 cites W2117310642 @default.
• W2016400514 cites W2395468591 @default.
• W2016400514 cites W52078519 @default.
• W2016400514 doi "https://doi.org/10.1089/dna.1997.16.1257" @default.
• W2016400514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9406998" @default.
• W2016400514 hasPublicationYear "1997" @default.
• W2016400514 type Work @default.
• W2016400514 sameAs 2016400514 @default.
• W2016400514 citedByCount "19" @default.
• W2016400514 countsByYear W20164005142012 @default.
• W2016400514 countsByYear W20164005142015 @default.
• W2016400514 countsByYear W20164005142018 @default.
• W2016400514 countsByYear W20164005142020 @default.
• W2016400514 crossrefType "journal-article" @default.
• W2016400514 hasAuthorship W2016400514A5001681968 @default.
• W2016400514 hasAuthorship W2016400514A5060059504 @default.
• W2016400514 hasAuthorship W2016400514A5083587616 @default.
• W2016400514 hasConcept C101819947 @default.
• W2016400514 hasConcept C104317684 @default.
• W2016400514 hasConcept C153911025 @default.
• W2016400514 hasConcept C181199279 @default.
• W2016400514 hasConcept C187882448 @default.
• W2016400514 hasConcept C189482833 @default.
• W2016400514 hasConcept C194583182 @default.
• W2016400514 hasConcept C2776671928 @default.
• W2016400514 hasConcept C36823959 @default.
• W2016400514 hasConcept C55493867 @default.
• W2016400514 hasConcept C86803240 @default.
• W2016400514 hasConcept C87644729 @default.
• W2016400514 hasConceptScore W2016400514C101819947 @default.
• W2016400514 hasConceptScore W2016400514C104317684 @default.
• W2016400514 hasConceptScore W2016400514C153911025 @default.
• W2016400514 hasConceptScore W2016400514C181199279 @default.
• W2016400514 hasConceptScore W2016400514C187882448 @default.
• W2016400514 hasConceptScore W2016400514C189482833 @default.
• W2016400514 hasConceptScore W2016400514C194583182 @default.
• W2016400514 hasConceptScore W2016400514C2776671928 @default.
• W2016400514 hasConceptScore W2016400514C36823959 @default.
• W2016400514 hasConceptScore W2016400514C55493867 @default.
• W2016400514 hasConceptScore W2016400514C86803240 @default.
• W2016400514 hasConceptScore W2016400514C87644729 @default.
• W2016400514 hasIssue "11" @default.
• W2016400514 hasLocation W20164005141 @default.
• W2016400514 hasLocation W20164005142 @default.
• W2016400514 hasOpenAccess W2016400514 @default.
• W2016400514 hasPrimaryLocation W20164005141 @default.
• W2016400514 hasRelatedWork W1541993819 @default.
• W2016400514 hasRelatedWork W1976843764 @default.
• W2016400514 hasRelatedWork W2022720479 @default.
• W2016400514 hasRelatedWork W2027888835 @default.
• W2016400514 hasRelatedWork W2029795834 @default.
• W2016400514 hasRelatedWork W2046240925 @default.
• W2016400514 hasRelatedWork W2147652847 @default.
• W2016400514 hasRelatedWork W2167085765 @default.
• W2016400514 hasRelatedWork W2800537687 @default.
• W2016400514 hasRelatedWork W3215633333 @default.
• W2016400514 hasVolume "16" @default.
• W2016400514 isParatext "false" @default.
• W2016400514 isRetracted "false" @default.

• next