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• W2016402578 abstract "The metabolic activation of carcinogens and some toxic chemicals appears to involve oxygenation in conformationally hindered positions in the chemical molecules. Oxygenation of xenobiotics in hindered positions is effected by cytochrome P-448 (LM4) but not by cytochrome P-450 (LM2). Substrate-interaction spectra show that cytochrome P-448 has an active site with a conformation different from that of cytochrome P-450. Induction of cytochrome P-448, as specifically measured by ethoxyresorufin O-deethylase activity, occurs in rat liver, kidney and lung after administration of the carcinogens, 3-methylcholanthrene, Aroclor 1254, 2-anthramine, safrole, 7,12-dimethylbenz[a]anthracene, MNNG and 2-acetamidofluorene. The doubtful carcinogens, saccharin, DDT and aldrin, resulted in no significant induction. The drugs paracetamol, antipyrine, imipramine and rifampicin resulted in diminished enzyme activity, indicating the absence of any induction of cytochrome P-448. In studies with the matched pairs of carcinogens and non-carcinogens, benzo[a]pyrene and benzo[e]pyrene, and 1,2,5,6-dibenzanthracene and anthracene, only the carcinogenic analogue resulted in induction of cytochrome P-448. With alpha- and beta-naphthylamine, both resulted in marked induction of cytochrome P-448 in liver, kidney and lung, indicating that both isomers might be carcinogenic." @default.
• W2016402578 created "2016-06-24" @default.
• W2016402578 creator A5006527207 @default.
• W2016402578 creator A5008306195 @default.
• W2016402578 creator A5087281525 @default.
• W2016402578 date "1984-01-01" @default.
• W2016402578 modified "2023-10-17" @default.
• W2016402578 title "Cytochrome P-448 and the activation of toxic chemicals and carcinogens" @default.
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• W2016402578 doi "https://doi.org/10.3109/00498258409151402" @default.
• W2016402578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6719936" @default.
• W2016402578 hasPublicationYear "1984" @default.
• W2016402578 type Work @default.
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• W2016402578 hasAuthorship W2016402578A5006527207 @default.
• W2016402578 hasAuthorship W2016402578A5008306195 @default.
• W2016402578 hasAuthorship W2016402578A5087281525 @default.

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