FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016403352> ?p ?o ?g. }

• W2016403352 endingPage "400" @default.
• W2016403352 startingPage "387" @default.
• W2016403352 abstract "In an effort to design and synthesize a new class of α-glucosidase inhibitor, we synthesized benzothiazole hybrid having benzohydrazide moiety (5). Compound 5 was reacted with various substituted aryl aldehyde to generate a small library of compounds 6-35. Synthesis of compounds was confirmed by the spectral information. These compounds were screened for their α-glucosidase activity. They showed a varying degree of α-glucosidase inhibition with IC50 values ranging between 5.31 and 53.34 μM. Compounds 6, 7, 9-16, 19, 21-30, 32-35 showed superior activity as compared to standard acarbose (IC50 = 906 ± 6.3 μM). This has identified a new class of α-glucosidase inhibitors. The predicted physico-chemical properties indicated the drug appropriateness for most of these compounds, as they obey Lipinski's rule of five (RO5). A hybrid B3LYP density functional theory (DFT) was employed for energy, minimization of 3D structures for all synthetic compounds using 6-311 + G(d,p) basis sets followed by molecular docking to explore their interactions with human intestinal C- and N-terminal domains of α-glucosidase. All compounds bind to the prospective allosteric site of the C- terminal domain, and consequently, may be considered as mixed inhibitors. It was hypothesized that both the dipole moment and H-bond interactions govern the biological activation of these compounds." @default.
• W2016403352 created "2016-06-24" @default.
• W2016403352 creator A5009297900 @default.
• W2016403352 creator A5021049882 @default.
• W2016403352 creator A5023610691 @default.
• W2016403352 creator A5040577138 @default.
• W2016403352 creator A5050202051 @default.
• W2016403352 creator A5064723726 @default.
• W2016403352 creator A5067965839 @default.
• W2016403352 creator A5077024542 @default.
• W2016403352 creator A5078032577 @default.
• W2016403352 date "2015-03-01" @default.
• W2016403352 modified "2023-09-24" @default.
• W2016403352 title "Synthesis of novel inhibitors of α-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies" @default.
• W2016403352 cites W1775101514 @default.
• W2016403352 cites W1973019551 @default.
• W2016403352 cites W1973388799 @default.
• W2016403352 cites W1976414153 @default.
• W2016403352 cites W1980401054 @default.
• W2016403352 cites W1981102023 @default.
• W2016403352 cites W1981411098 @default.
• W2016403352 cites W1981676565 @default.
• W2016403352 cites W1983284328 @default.
• W2016403352 cites W1983347300 @default.
• W2016403352 cites W1993160816 @default.
• W2016403352 cites W1996978280 @default.
• W2016403352 cites W2000658185 @default.
• W2016403352 cites W2003070312 @default.
• W2016403352 cites W2003460626 @default.
• W2016403352 cites W2004768695 @default.
• W2016403352 cites W2008043980 @default.
• W2016403352 cites W2009309012 @default.
• W2016403352 cites W2018919593 @default.
• W2016403352 cites W2020411326 @default.
• W2016403352 cites W2026078328 @default.
• W2016403352 cites W2027132936 @default.
• W2016403352 cites W2027996680 @default.
• W2016403352 cites W2029240286 @default.
• W2016403352 cites W2029667189 @default.
• W2016403352 cites W2030020472 @default.
• W2016403352 cites W2034723345 @default.
• W2016403352 cites W2046229956 @default.
• W2016403352 cites W2048498907 @default.
• W2016403352 cites W2050723215 @default.
• W2016403352 cites W2050812286 @default.
• W2016403352 cites W2056278454 @default.
• W2016403352 cites W2057903963 @default.
• W2016403352 cites W2058658653 @default.
• W2016403352 cites W2067114599 @default.
• W2016403352 cites W2075209098 @default.
• W2016403352 cites W2083968759 @default.
• W2016403352 cites W2085311522 @default.
• W2016403352 cites W2090294047 @default.
• W2016403352 cites W2093479140 @default.
• W2016403352 cites W2104268626 @default.
• W2016403352 cites W2118490902 @default.
• W2016403352 cites W2125541155 @default.
• W2016403352 cites W2131109213 @default.
• W2016403352 cites W2145441965 @default.
• W2016403352 cites W2146126160 @default.
• W2016403352 cites W2165013954 @default.
• W2016403352 cites W2167377129 @default.
• W2016403352 cites W2178164719 @default.
• W2016403352 cites W2180771765 @default.
• W2016403352 cites W2324283014 @default.
• W2016403352 cites W2326309404 @default.
• W2016403352 cites W2515246543 @default.
• W2016403352 doi "https://doi.org/10.1016/j.ejmech.2015.01.009" @default.
• W2016403352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25585009" @default.
• W2016403352 hasPublicationYear "2015" @default.
• W2016403352 type Work @default.
• W2016403352 sameAs 2016403352 @default.
• W2016403352 citedByCount "149" @default.
• W2016403352 countsByYear W20164033522015 @default.
• W2016403352 countsByYear W20164033522016 @default.
• W2016403352 countsByYear W20164033522017 @default.
• W2016403352 countsByYear W20164033522018 @default.
• W2016403352 countsByYear W20164033522019 @default.
• W2016403352 countsByYear W20164033522020 @default.
• W2016403352 countsByYear W20164033522021 @default.
• W2016403352 countsByYear W20164033522022 @default.
• W2016403352 countsByYear W20164033522023 @default.
• W2016403352 crossrefType "journal-article" @default.
• W2016403352 hasAuthorship W2016403352A5009297900 @default.
• W2016403352 hasAuthorship W2016403352A5021049882 @default.
• W2016403352 hasAuthorship W2016403352A5023610691 @default.
• W2016403352 hasAuthorship W2016403352A5040577138 @default.
• W2016403352 hasAuthorship W2016403352A5050202051 @default.
• W2016403352 hasAuthorship W2016403352A5064723726 @default.
• W2016403352 hasAuthorship W2016403352A5067965839 @default.
• W2016403352 hasAuthorship W2016403352A5077024542 @default.
• W2016403352 hasAuthorship W2016403352A5078032577 @default.
• W2016403352 hasConcept C159110408 @default.
• W2016403352 hasConcept C178790620 @default.
• W2016403352 hasConcept C181199279 @default.
• W2016403352 hasConcept C185592680 @default.
• W2016403352 hasConcept C21951064 @default.
• W2016403352 hasConcept C2776568683 @default.

• next