FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016405286> ?p ?o ?g. }

• W2016405286 endingPage "64" @default.
• W2016405286 startingPage "60" @default.
• W2016405286 abstract "NRTI-induced host toxicity is proposed to involve cellular mitochondrial DNA (mtDNA) depletion. Determinants of cellular mtDNA copy number from HIV-infected patients receiving HAART and HIV-seronegative controls were investigated from subcutaneous fat samples, and relation with antiretroviral regimen was studied.HIV-infected patients receiving HAART (n = 50), HIV-infected patients not currently under HAART regimen (n = 2) and HIV-seronegative controls (n = 9) of similar age and BMI were enrolled prospectively when undergoing Coleman's lipostructure for correction of facial lipoatrophy or plastic surgery, respectively. After centrifugation, abdominal fat tissue was collected and stored at -80 degrees C. MtDNA analysis was blindly performed after a total DNA extraction from adipose tissue, followed by a real-time PCR quantification. The log of mtDNA copies/cell in adipose tissue [log(DNA)] was compared between groups by means of analysis of variance.The log(DNA) in adipose tissue of HIV-infected patients was significantly lower than in the HIV-seronegative control group (P < 0.0001). In HIV-infected patients, log(DNA) was significantly reduced in the 50 NRTI-treated patients (P < 0.01), but not when considering mtDNA level according to the use of PI or NNRTI in current HAART regimen. In NRTI-treated patients, only stavudine (n = 20) and didanosine (n=14) were significantly and independently associated with reduced mtDNA level (P < 0.0001 and <0.05, respectively). Currently stavudine or didanosine-treated patients had a significant reduced mtDNA level compared to past users (P < 0.0001 and <0.05, respectively). Other clinical, biological, and immuno-virological variables than NRTI did not correlate significantly to adipocyte mtDNA level.This study supports that current treatment by NRTI is a main determinant of mtDNA depletion in adipose tissue of HIV-seropositive patients with peripheral fat wasting. Stavudine or didanosine current intake is significantly associated with mtDNA depletion in vivo, that could be reversible after the discontinuation of these molecules, when considering mtDNA level according to current use versus past use of these molecules." @default.
• W2016405286 created "2016-06-24" @default.
• W2016405286 creator A5002216203 @default.
• W2016405286 creator A5005958279 @default.
• W2016405286 creator A5014874487 @default.
• W2016405286 creator A5019341717 @default.
• W2016405286 creator A5026234029 @default.
• W2016405286 creator A5027494414 @default.
• W2016405286 creator A5042447894 @default.
• W2016405286 creator A5051977806 @default.
• W2016405286 creator A5057002514 @default.
• W2016405286 creator A5058773961 @default.
• W2016405286 creator A5066365321 @default.
• W2016405286 date "2005-05-01" @default.
• W2016405286 modified "2023-10-18" @default.
• W2016405286 title "Mitochondrial DNA depletion in adipose tissue of HIV-infected patients with peripheral lipoatrophy" @default.
• W2016405286 cites W1589435521 @default.
• W2016405286 cites W1990006539 @default.
• W2016405286 cites W1998660799 @default.
• W2016405286 cites W2013711685 @default.
• W2016405286 cites W2056324634 @default.
• W2016405286 cites W2076562284 @default.
• W2016405286 cites W2080298727 @default.
• W2016405286 cites W2084332399 @default.
• W2016405286 cites W2089557992 @default.
• W2016405286 cites W2126327126 @default.
• W2016405286 cites W2131203391 @default.
• W2016405286 cites W2136647574 @default.
• W2016405286 cites W2141163306 @default.
• W2016405286 cites W2147865715 @default.
• W2016405286 cites W2150961630 @default.
• W2016405286 cites W2163492123 @default.
• W2016405286 cites W2316412239 @default.
• W2016405286 cites W2328134361 @default.
• W2016405286 doi "https://doi.org/10.1016/j.jcv.2004.09.027" @default.
• W2016405286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15797366" @default.
• W2016405286 hasPublicationYear "2005" @default.
• W2016405286 type Work @default.
• W2016405286 sameAs 2016405286 @default.
• W2016405286 citedByCount "43" @default.
• W2016405286 countsByYear W20164052862012 @default.
• W2016405286 countsByYear W20164052862013 @default.
• W2016405286 countsByYear W20164052862014 @default.
• W2016405286 countsByYear W20164052862015 @default.
• W2016405286 countsByYear W20164052862018 @default.
• W2016405286 crossrefType "journal-article" @default.
• W2016405286 hasAuthorship W2016405286A5002216203 @default.
• W2016405286 hasAuthorship W2016405286A5005958279 @default.
• W2016405286 hasAuthorship W2016405286A5014874487 @default.
• W2016405286 hasAuthorship W2016405286A5019341717 @default.
• W2016405286 hasAuthorship W2016405286A5026234029 @default.
• W2016405286 hasAuthorship W2016405286A5027494414 @default.
• W2016405286 hasAuthorship W2016405286A5042447894 @default.
• W2016405286 hasAuthorship W2016405286A5051977806 @default.
• W2016405286 hasAuthorship W2016405286A5057002514 @default.
• W2016405286 hasAuthorship W2016405286A5058773961 @default.
• W2016405286 hasAuthorship W2016405286A5066365321 @default.
• W2016405286 hasConcept C104317684 @default.
• W2016405286 hasConcept C126322002 @default.
• W2016405286 hasConcept C142462285 @default.
• W2016405286 hasConcept C171089720 @default.
• W2016405286 hasConcept C203014093 @default.
• W2016405286 hasConcept C24586158 @default.
• W2016405286 hasConcept C2777071529 @default.
• W2016405286 hasConcept C2777447569 @default.
• W2016405286 hasConcept C2779546735 @default.
• W2016405286 hasConcept C2779889181 @default.
• W2016405286 hasConcept C2780941825 @default.
• W2016405286 hasConcept C2781413609 @default.
• W2016405286 hasConcept C29730261 @default.
• W2016405286 hasConcept C2993143319 @default.
• W2016405286 hasConcept C3013748606 @default.
• W2016405286 hasConcept C55493867 @default.
• W2016405286 hasConcept C71924100 @default.
• W2016405286 hasConcept C86803240 @default.
• W2016405286 hasConcept C90924648 @default.
• W2016405286 hasConceptScore W2016405286C104317684 @default.
• W2016405286 hasConceptScore W2016405286C126322002 @default.
• W2016405286 hasConceptScore W2016405286C142462285 @default.
• W2016405286 hasConceptScore W2016405286C171089720 @default.
• W2016405286 hasConceptScore W2016405286C203014093 @default.
• W2016405286 hasConceptScore W2016405286C24586158 @default.
• W2016405286 hasConceptScore W2016405286C2777071529 @default.
• W2016405286 hasConceptScore W2016405286C2777447569 @default.
• W2016405286 hasConceptScore W2016405286C2779546735 @default.
• W2016405286 hasConceptScore W2016405286C2779889181 @default.
• W2016405286 hasConceptScore W2016405286C2780941825 @default.
• W2016405286 hasConceptScore W2016405286C2781413609 @default.
• W2016405286 hasConceptScore W2016405286C29730261 @default.
• W2016405286 hasConceptScore W2016405286C2993143319 @default.
• W2016405286 hasConceptScore W2016405286C3013748606 @default.
• W2016405286 hasConceptScore W2016405286C55493867 @default.
• W2016405286 hasConceptScore W2016405286C71924100 @default.
• W2016405286 hasConceptScore W2016405286C86803240 @default.
• W2016405286 hasConceptScore W2016405286C90924648 @default.
• W2016405286 hasIssue "1" @default.
• W2016405286 hasLocation W20164052861 @default.
• W2016405286 hasLocation W20164052862 @default.

• next