FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016407072> ?p ?o ?g. }

• W2016407072 endingPage "263" @default.
• W2016407072 startingPage "253" @default.
• W2016407072 abstract "The evolutionary responses of infectious pathogens often have ruinous consequences for the control of disease spread in the population. Drug resistance is a well-documented instance that is generally driven by the selective pressure of drugs on both the replication of the pathogen within hosts and its transmission between hosts. Management of drug resistance therefore requires the development of treatment strategies that can impede the emergence and spread of resistance in the population. This study evaluates various treatment strategies for influenza infection as a case study by comparing the long-term epidemiological outcomes predicted by deterministic and stochastic versions of a homogeneously mixing (mean-field) model and those predicted by a heterogeneous model that incorporates spatial pair-wise correlation. We discuss the importance of three major parameters in our evaluation: the basic reproduction number, the population level of treatment, and the degree of clustering as a key parameter determining the structure of heterogeneous interactions. The results show that, as a common feature in all models, high treatment levels during the early stages of disease outset can result in large resistant outbreaks, with the possibility of a second wave of infection appearing in the pair-approximation model. Our simulations demonstrate that, if the basic reproduction number exceeds a threshold value, the population-wide spread of the resistant pathogen emerges more rapidly in the pair-approximation model with significantly lower treatment levels than in the homogeneous models. We tested an antiviral strategy that delays the onset of aggressive treatment for a certain amount of time after the onset of the outbreak. The findings indicate that the overall disease incidence is reduced as the degree of clustering increases, and a longer delay should be considered for implementing the large-scale treatment." @default.
• W2016407072 created "2016-06-24" @default.
• W2016407072 creator A5023372862 @default.
• W2016407072 creator A5061218864 @default.
• W2016407072 creator A5071707478 @default.
• W2016407072 creator A5085586304 @default.
• W2016407072 date "2009-07-01" @default.
• W2016407072 modified "2023-10-14" @default.
• W2016407072 title "A comparative evaluation of modelling strategies for the effect of treatment and host interactions on the spread of drug resistance" @default.
• W2016407072 cites W1823502509 @default.
• W2016407072 cites W1976372006 @default.
• W2016407072 cites W1986547558 @default.
• W2016407072 cites W1989685582 @default.
• W2016407072 cites W1992115679 @default.
• W2016407072 cites W1998962894 @default.
• W2016407072 cites W2016469924 @default.
• W2016407072 cites W2016767093 @default.
• W2016407072 cites W2016842303 @default.
• W2016407072 cites W2030539428 @default.
• W2016407072 cites W2030540141 @default.
• W2016407072 cites W2046313164 @default.
• W2016407072 cites W2064168048 @default.
• W2016407072 cites W2076416557 @default.
• W2016407072 cites W2078212821 @default.
• W2016407072 cites W2078980460 @default.
• W2016407072 cites W2086167141 @default.
• W2016407072 cites W2100989087 @default.
• W2016407072 cites W2103078323 @default.
• W2016407072 cites W2116562254 @default.
• W2016407072 cites W2121472688 @default.
• W2016407072 cites W2126433377 @default.
• W2016407072 cites W2126887879 @default.
• W2016407072 cites W2128868625 @default.
• W2016407072 cites W2149087734 @default.
• W2016407072 cites W2152283024 @default.
• W2016407072 cites W2156537900 @default.
• W2016407072 cites W2157177671 @default.
• W2016407072 cites W2162278568 @default.
• W2016407072 cites W2162707016 @default.
• W2016407072 cites W2168236157 @default.
• W2016407072 doi "https://doi.org/10.1016/j.jtbi.2009.03.029" @default.
• W2016407072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7127136" @default.
• W2016407072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19344730" @default.
• W2016407072 hasPublicationYear "2009" @default.
• W2016407072 type Work @default.
• W2016407072 sameAs 2016407072 @default.
• W2016407072 citedByCount "11" @default.
• W2016407072 countsByYear W20164070722012 @default.
• W2016407072 countsByYear W20164070722013 @default.
• W2016407072 countsByYear W20164070722016 @default.
• W2016407072 countsByYear W20164070722018 @default.
• W2016407072 countsByYear W20164070722019 @default.
• W2016407072 crossrefType "journal-article" @default.
• W2016407072 hasAuthorship W2016407072A5023372862 @default.
• W2016407072 hasAuthorship W2016407072A5061218864 @default.
• W2016407072 hasAuthorship W2016407072A5071707478 @default.
• W2016407072 hasAuthorship W2016407072A5085586304 @default.
• W2016407072 hasBestOaLocation W20164070721 @default.
• W2016407072 hasConcept C114851261 @default.
• W2016407072 hasConcept C142724271 @default.
• W2016407072 hasConcept C144024400 @default.
• W2016407072 hasConcept C149782125 @default.
• W2016407072 hasConcept C149923435 @default.
• W2016407072 hasConcept C1627819 @default.
• W2016407072 hasConcept C204264503 @default.
• W2016407072 hasConcept C2779134260 @default.
• W2016407072 hasConcept C2908647359 @default.
• W2016407072 hasConcept C33923547 @default.
• W2016407072 hasConcept C524204448 @default.
• W2016407072 hasConcept C54355233 @default.
• W2016407072 hasConcept C71924100 @default.
• W2016407072 hasConcept C86803240 @default.
• W2016407072 hasConceptScore W2016407072C114851261 @default.
• W2016407072 hasConceptScore W2016407072C142724271 @default.
• W2016407072 hasConceptScore W2016407072C144024400 @default.
• W2016407072 hasConceptScore W2016407072C149782125 @default.
• W2016407072 hasConceptScore W2016407072C149923435 @default.
• W2016407072 hasConceptScore W2016407072C1627819 @default.
• W2016407072 hasConceptScore W2016407072C204264503 @default.
• W2016407072 hasConceptScore W2016407072C2779134260 @default.
• W2016407072 hasConceptScore W2016407072C2908647359 @default.
• W2016407072 hasConceptScore W2016407072C33923547 @default.
• W2016407072 hasConceptScore W2016407072C524204448 @default.
• W2016407072 hasConceptScore W2016407072C54355233 @default.
• W2016407072 hasConceptScore W2016407072C71924100 @default.
• W2016407072 hasConceptScore W2016407072C86803240 @default.
• W2016407072 hasIssue "2" @default.
• W2016407072 hasLocation W20164070721 @default.
• W2016407072 hasLocation W20164070722 @default.
• W2016407072 hasLocation W20164070723 @default.
• W2016407072 hasLocation W20164070724 @default.
• W2016407072 hasOpenAccess W2016407072 @default.
• W2016407072 hasPrimaryLocation W20164070721 @default.
• W2016407072 hasRelatedWork W2032448025 @default.
• W2016407072 hasRelatedWork W2230721379 @default.
• W2016407072 hasRelatedWork W2291447000 @default.
• W2016407072 hasRelatedWork W2356839139 @default.
• W2016407072 hasRelatedWork W2376250553 @default.

• next