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- W2016408284 abstract "Soybean trypsin inhibitor (SBI) was found to inhibit transformation of human lymphocytes induced by mitogens (leucoagglutinin, concanavalin A, NaIO 4 ) or in mixed lymphocyte reaction (MLR). SBI covalently cross-linked to Sepharose beads inhibited the MLR and mitogen stimulation virtually completely. We have confirmed the work of others which showed that the synthetic anti-proteases e-aminocaproic acid and tosyl-L-lysyl-chloromethane (TLCK) also inhibited mitogen-induced blastogenesis and we have shown that phenylmethylsulfonylfluoride was effective also; all of these agents were found to inhibit the MLR as well. SBI and TLCK were most inhibitory when added along with mitogen or when mixing allogeneic cells in a MLR; significant decrease in inhibition was noted when TLCK was added 1 h after mitogen. These data support the hypothesis that protease action at a cell surface is an essential early event common to all types of lymphocyte transformation." @default.
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- W2016408284 date "1975-12-01" @default.
- W2016408284 modified "2023-09-27" @default.
- W2016408284 title "Inhibition of Lymphocyte Transformation: Effect of Soy Bean Trypsin Inhibitor and Synthetic Anti-Proteases" @default.
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- W2016408284 doi "https://doi.org/10.1139/o75-182" @default.
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