Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016409877> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2016409877 abstract "The action of Lonidamine (LND), a dichlorinated derivative of indazole-3-carboxylic acid, on the membrane and cytoskeleton of Ehrlich tumor cells was investigated. A remarkable alteration in the molecular organization of the plasma membrane was observed. In particular, changes of plasma membrane and mitochondrial membrane protein distribution were induced by the drug. These membrane alterations were positively related to a rearrangement of microfilaments. In particular, characteristic ring-like structures of actin filaments were observed after 8 h of LND treatment. Intracellular calcium imbalance appeared-to be necessary to produce such peculiar structures. In fact, the administration of a calcium ionophore prevented the actin modifications induced by LND treatment while the simultaneous exposure to the antineoplastic drug verapamil, also considered a calcium channel blocker, was ineffective. The results reported herein suggest that the cytoskeleton as well as cell membranes might be involved in the cytotoxic action of LND and that they could share a common mechanism related to the calcium homeostasis. Moreover, Ehrlich tumor cells display a specific, peculiar rearrangement of F-actin filaments which can be considered as a marker effect of LND." @default.
- W2016409877 created "2016-06-24" @default.
- W2016409877 creator A5021070443 @default.
- W2016409877 creator A5023372046 @default.
- W2016409877 creator A5030021056 @default.
- W2016409877 creator A5064623322 @default.
- W2016409877 date "1994-03-01" @default.
- W2016409877 modified "2023-09-27" @default.
- W2016409877 title "THE MODE OF ACTION OF THE ANTITUMOR AGENT LONIDAMINE INVOLVES CALCIUM-ASSOCIATED ACTIN FILAMENT ROUNDING" @default.
- W2016409877 doi "https://doi.org/10.3892/or.1.2.387" @default.
- W2016409877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21607371" @default.
- W2016409877 hasPublicationYear "1994" @default.
- W2016409877 type Work @default.
- W2016409877 sameAs 2016409877 @default.
- W2016409877 citedByCount "0" @default.
- W2016409877 crossrefType "journal-article" @default.
- W2016409877 hasAuthorship W2016409877A5021070443 @default.
- W2016409877 hasAuthorship W2016409877A5023372046 @default.
- W2016409877 hasAuthorship W2016409877A5030021056 @default.
- W2016409877 hasAuthorship W2016409877A5064623322 @default.
- W2016409877 hasConcept C12554922 @default.
- W2016409877 hasConcept C125705527 @default.
- W2016409877 hasConcept C142669718 @default.
- W2016409877 hasConcept C1491633281 @default.
- W2016409877 hasConcept C178790620 @default.
- W2016409877 hasConcept C181199279 @default.
- W2016409877 hasConcept C185592680 @default.
- W2016409877 hasConcept C189040839 @default.
- W2016409877 hasConcept C23265538 @default.
- W2016409877 hasConcept C2993400109 @default.
- W2016409877 hasConcept C3620293 @default.
- W2016409877 hasConcept C51705589 @default.
- W2016409877 hasConcept C519063684 @default.
- W2016409877 hasConcept C55493867 @default.
- W2016409877 hasConcept C86803240 @default.
- W2016409877 hasConcept C95444343 @default.
- W2016409877 hasConceptScore W2016409877C12554922 @default.
- W2016409877 hasConceptScore W2016409877C125705527 @default.
- W2016409877 hasConceptScore W2016409877C142669718 @default.
- W2016409877 hasConceptScore W2016409877C1491633281 @default.
- W2016409877 hasConceptScore W2016409877C178790620 @default.
- W2016409877 hasConceptScore W2016409877C181199279 @default.
- W2016409877 hasConceptScore W2016409877C185592680 @default.
- W2016409877 hasConceptScore W2016409877C189040839 @default.
- W2016409877 hasConceptScore W2016409877C23265538 @default.
- W2016409877 hasConceptScore W2016409877C2993400109 @default.
- W2016409877 hasConceptScore W2016409877C3620293 @default.
- W2016409877 hasConceptScore W2016409877C51705589 @default.
- W2016409877 hasConceptScore W2016409877C519063684 @default.
- W2016409877 hasConceptScore W2016409877C55493867 @default.
- W2016409877 hasConceptScore W2016409877C86803240 @default.
- W2016409877 hasConceptScore W2016409877C95444343 @default.
- W2016409877 hasLocation W20164098771 @default.
- W2016409877 hasLocation W20164098772 @default.
- W2016409877 hasOpenAccess W2016409877 @default.
- W2016409877 hasPrimaryLocation W20164098771 @default.
- W2016409877 hasRelatedWork W1969809609 @default.
- W2016409877 hasRelatedWork W1973538529 @default.
- W2016409877 hasRelatedWork W1974249706 @default.
- W2016409877 hasRelatedWork W1976346706 @default.
- W2016409877 hasRelatedWork W1990519098 @default.
- W2016409877 hasRelatedWork W2005142415 @default.
- W2016409877 hasRelatedWork W2008650709 @default.
- W2016409877 hasRelatedWork W2009141581 @default.
- W2016409877 hasRelatedWork W2019753243 @default.
- W2016409877 hasRelatedWork W2031472508 @default.
- W2016409877 hasRelatedWork W2053448942 @default.
- W2016409877 hasRelatedWork W2061261613 @default.
- W2016409877 hasRelatedWork W2146379426 @default.
- W2016409877 hasRelatedWork W2151029872 @default.
- W2016409877 hasRelatedWork W2185284085 @default.
- W2016409877 hasRelatedWork W2469566618 @default.
- W2016409877 hasRelatedWork W2522709986 @default.
- W2016409877 hasRelatedWork W3194341678 @default.
- W2016409877 hasRelatedWork W6106852 @default.
- W2016409877 hasRelatedWork W922717251 @default.
- W2016409877 isParatext "false" @default.
- W2016409877 isRetracted "false" @default.
- W2016409877 magId "2016409877" @default.
- W2016409877 workType "article" @default.