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• W2016412049 abstract "We have investigated the involvement of human apolipoprotein A-IV (apoA-IV) in gastric acid secretion and ulcer formation in recently generated apoA-IV transgenic mice. Compared to control littermates, transgenic animals showed a gastric acid secretion decreased by 43-77% whereas only slight variations were observed in the different cell population densities within the gastric mucosa. In addition, no variation in gastrin levels was observed. Transgenics were protected against indomethacin-induced ulcer formation, with lesions diminishing by 45 to 64% compared to controls. These results indicate that endogenous apoA-IV expression can regulate gastric acid secretion and ulcer development." @default.
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• W2016412049 date "1999-10-22" @default.
• W2016412049 modified "2023-09-25" @default.
• W2016412049 title "Human apolipoprotein A-IV reduces gastric acid secretion and diminishes ulcer formation in transgenic mice" @default.
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• W2016412049 doi "https://doi.org/10.1016/s0014-5793(99)01332-0" @default.
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