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• W2016415632 abstract "Histone deacetylase inhibitors (HDACi) can induce hyperacetylation of both histone and non-histone target resulting in epigenetic reprogramming and altered activity, stability and localisation of non-histone proteins to ultimately mediate diverse biological effects on cancer cells and their microenvironment. Clinical trials have demonstrated single agent HDACi to have activity in hematological malignancies, in particular T-cell lymphoma and Hodgkin lymphoma. Combination strategies with standard therapies based on pre-clinical data are being employed with significant success due to their excellent side effect profile. Correlative studies will provide valuable information on the sub-groups of patients more likely to respond or be resistant to HDACi therapy, while long-term monitoring for toxicities is also needed." @default.
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• W2016415632 date "2010-08-17" @default.
• W2016415632 modified "2023-09-23" @default.
• W2016415632 title "Overview of Histone Deacetylase Inhibitors in Haematological Malignancies" @default.
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• W2016415632 doi "https://doi.org/10.3390/ph3082674" @default.
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