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• W2016427904 abstract "Prognosis of peripheral artery disease (PAD), especially critical limb ischemia, is very poor despite the development of endovascular therapy and bypass surgery. Many patients result in leg amputation and, therefore, vascular regenerative therapy is expected in this field. Gene therapy using vascular endothelial growth factor is the first step of vascular regenerative therapy, but did not confirm effectiveness in a large-scale randomized comparative study. Based on animal experiments, bone marrow mononuclear cells (MNCs), peripheral blood MNCs were used as the cell source for regenerative therapy. Those cells were confirmed to be effective to decrease rest pain and ulcer size, but its effect was not fully satisfied. Mesenchymal stem cells (MSCs) are expected as an effective cell source for vascular regeneration and clinical studies are ongoing, because the cells are able to differentiate into various cell types and produce a significant amount of vascular growth factors. Of vascular regeneration therapy, peripheral MNCs and bone marrow MNCs were recognized as advanced medical technology but do not attain to the standard therapy. However, clinical use of MSCs have already started, and induced pluripotent stem cells are surely promising tool for vascular regeneration therapy although further basic studies are required for clinical application." @default.
• W2016427904 created "2016-06-24" @default.
• W2016427904 creator A5055701247 @default.
• W2016427904 creator A5058052385 @default.
• W2016427904 date "2013-01-01" @default.
• W2016427904 modified "2023-09-23" @default.
• W2016427904 title "Clinical Application of Vascular Regenerative Therapy for Peripheral Artery Disease" @default.
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• W2016427904 doi "https://doi.org/10.1155/2013/179730" @default.
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