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- W2016428375 abstract "Splenectomy before immunization of mice with syngeneic SV40-transformed cells markedly augmented the specific cell-mediated immune response against the corresponding tumor-associated antigens as measured by an in vitro51Cr-release assay and an in vivo tumor-cell neutralization assay. This augmentation was not dependent on the time interval between splenectomy and antigen immunization. By performing reconstitution experiments, it was found that thymus-derived cells in spleens of normal syngeneic mice abolished the splenectomy-induced augmentation of immune response. It is inferred that the resident population which normally operates in spleen-intact mice to suppress the specific immune response against SV40-induced tumor-associated antigens is T-cell." @default.
- W2016428375 created "2016-06-24" @default.
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- W2016428375 date "1979-06-01" @default.
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- W2016428375 title "Augmentation of specific immune response against syngeneic SV40-induced tumor-associated antigens by splenectomy" @default.
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- W2016428375 doi "https://doi.org/10.1016/0008-8749(79)90381-2" @default.
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